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. 2019 Jul 23;9(1):10639.
doi: 10.1038/s41598-019-47143-2.

The prognostic role of platelet-to-lymphocyte ratio in patients with acute heart failure: A cohort study

Gui-Lian Ye  1 , Qiang Chen  2 , Xueyu Chen  2 , Ying-Ying Liu  2 , Ting-Ting Yin  2 , Qing-He Meng  2 , Ying-Chao Liu  2 , Huai-Qing Wei  2 , Qing-Hua Zhou  3
Affiliations

The prognostic role of platelet-to-lymphocyte ratio in patients with acute heart failure: A cohort study

Gui-Lian Ye et al. Sci Rep. .

Abstract

Identification of rapid, inexpensive, and reliable prognostic factors can improve survival estimation and guide healthcare in patients with acute heart failure (AHF). In this study, we aimed to determine the prognostic value of the platelet-to-lymphocyte ratio (PLR) in patients with AHF. A total of 443 patients from two hospitals met the inclusion criteria from January 2010 to December 2017. Univariate and multivariate Cox analyses were performed to determine the association of PLR with survival. All-cause mortality was analysed using the Kaplan-Meier method. The 6-month survival rate for patients according to PLR quartiles (<110.63, 110.63-139.23, 139.23-177.17, and >177.17) were 90.09%, 76.79%, 50.07%, and 37.27%, respectively (p < 0.001). Univariate analysis identified high PLR (>110.63), old age (≥73 years), smoking habit, low estimated glomerular filtration rate (<57), and high platelet count (≥198 × 109/l) as poor prognostic factors for survival. In the multivariate analysis, after adjusting for confounding factors, the third (hazard ratio [HR] = 3.118, 95% confidence interval [CI] = 1.668-5.386, p < 0.001) and fourth (HR = 2.437, 95% CI = 1.302-3.653, p < 0.001) quartiles of PLR were identified as independent prognostic factors in patients with AHF. A higher PLR was associated with poor clinical outcomes in patients with AHF and might be a novel marker in AHF management.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The study cohort flow diagram.
Figure 2
Figure 2
The association between platelet, and lymphocyte counts with platelet-to-lymphocyte ratio (PLR) levels of patients with acute heart failure.
Figure 3
Figure 3
Kaplan–Meier curve stratified by platelet-to-lymphocyte ratio according to quartiles regarding all-cause survival for patients with acute heart failure.
See this image and copyright information in PMC

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