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Comment
. 2019 Sep;29(9):690-691.
doi: 10.1038/s41422-019-0207-y.

Lnc(ing) interferon production and action

Ganes C Sen  1 , Bryan R G Williams  2   3
Affiliations
Comment

Lnc(ing) interferon production and action

Ganes C Sen et al. Cell Res. 2019 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Viral pathogen associated molecular patterns activate the transcription factor IRF3, driving IFN-I production that in turn induces the production of lncLrcc55-AS. The latter binds to the protein phosphatase methyltransferase PME-1 enhancing its activity to demethylate the phosphatase PP2A and inactivate it, thereby maintaining IRF3 in a transcriptionally active state. The result is an enhancement of IFN-I production
See this image and copyright information in PMC

Comment on

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