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Review
. 2019 Jul 9:10:834.
doi: 10.3389/fpls.2019.00834. eCollection 2019.

Arctium Species Secondary Metabolites Chemodiversity and Bioactivities

Dongdong Wang  1   2   3 , Alexandru Sabin Bădărau  4 , Mallappa Kumara Swamy  5 , Subrata Shaw  6 , Filippo Maggi  7 , Luiz Everson da Silva  8 , Víctor López  9   10 , Andy Wai Kan Yeung  11 , Andrei Mocan  12   13 , Atanas G Atanasov  2   3   14
Affiliations
Review

Arctium Species Secondary Metabolites Chemodiversity and Bioactivities

Dongdong Wang et al. Front Plant Sci. .

Abstract

Arctium species are known for a variety of pharmacological effects due to their diverse volatile and non-volatile secondary metabolites. Representatives of Arctium species contain non-volatile compounds including lignans, fatty acids, acetylenic compounds, phytosterols, polysaccharides, caffeoylquinic acid derivatives, flavonoids, terpenes/terpenoids and volatile compounds such as hydrocarbons, aldehydes, methoxypyrazines, carboxylic and fatty acids, monoterpenes and sesquiterpenes. Arctium species also possess bioactive properties such as anti-cancer, anti-diabetic, anti-oxidant, hepatoprotective, gastroprotective, antibacterial, antiviral, antimicrobial, anti-allergic, and anti-inflammatory effects. This review aims to provide a complete overview of the chemistry and biological activities of the secondary metabolites found in therapeutically used Arctium species. Summary of pharmacopeias and monographs contents indicating the relevant phytochemicals and therapeutic effects are also discussed, along with possible safety considerations.

Keywords: Arctium species; bioactivity; chemodiversity; non-volatile compounds; secondary metabolites; volatile compounds.

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Figures

FIGURE 1
FIGURE 1
Plants of Arctium. (A) Arctium lappa; (B) Arctium minus; (C) Arctium tomentosum; (D) Arctium nemorosum.
FIGURE 2
FIGURE 2
Chemical structures of several relevant components present in Arctium species.
See this image and copyright information in PMC

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