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. 2019 Aug 2;21(15):6005-6010.
doi: 10.1021/acs.orglett.9b02152. Epub 2019 Jul 24.

Four-Component Photoredox-Mediated Azidoalkoxy-trifluoromethylation of Alkenes

Guillaume Levitre  1 , Guillaume Dagousset  2 , Elsa Anselmi  2 , Béatrice Tuccio  3 , Emmanuel Magnier  2 , Géraldine Masson  1
Affiliations

Four-Component Photoredox-Mediated Azidoalkoxy-trifluoromethylation of Alkenes

Guillaume Levitre et al. Org Lett. .

Abstract

We report herein an efficient four-component photoredox-catalyzed reaction. Under the optimized conditions using [Ru(bpy)3(PF6)2] as the photocatalyst, a wide range of terminal and internal alkenes can efficiently undergo azidoalkoxy-trifluoromethylation in the presence of Umemoto's reagent, carbonyl compound, and TMSN3, giving rise to original and highly complex molecules in a single operation.

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