Synapses in the heart: sympathetic neuro-cardiac interaction modulates myocardial remodelling in healthy and diseased myocardium

Shin-Haw Lee^{1

2}, Da Hye Kim^{1

2}

Affiliations

¹ Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada, M5G 1M1.
² Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, M5S 1M8.

Free article

Comment

Shin-Haw Lee et al. J Physiol. 2019 Sep.

Free article

. 2019 Sep;597(17):4441-4442.

doi: 10.1113/JP278421. Epub 2019 Jul 30.

Shin-Haw Lee^{1

2}, Da Hye Kim^{1

2}

¹ Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada, M5G 1M1.
² Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, M5S 1M8.

No abstract available

Keywords: Cardiac muscle; adrenergic receptors; cardiac myocytes; sympathetic nervous system.

Comment on

Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery.
Pianca N, Di Bona A, Lazzeri E, Costantini I, Franzoso M, Prando V, Armani A, Rizzo S, Fedrigo M, Angelini A, Basso C, Pavone FS, Rubart M, Sacconi L, Zaglia T, Mongillo M. Pianca N, et al. J Physiol. 2019 Jul;597(14):3639-3656. doi: 10.1113/JP276200. Epub 2019 Jun 17. J Physiol. 2019. PMID: 31116413

1. Baker JG (2005). The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol 144, 317-322.
1. Kreipke RE & Birren SJ (2015). Innervating sympathetic neurons regulate heart size and the timing of cardiomyocyte cell cycle withdrawal. J Physiol 593, 5057-5073.
1. Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ & Simpson PC (2017). Adrenergic receptors in individual ventricular myocytes: the beta-1 and alpha-1b are in all cells, the alpha-1a is in a subpopulation, and the beta-2 and beta-3 are mostly absent. Circ Res 120, 1103-1115.
1. Pianca N, Bona AD, Lazzeri E, Costantini I, Franzoso M, Prando V, Armani A, Rizzo S, Fedrigo M, Angelini A, Basso C, Pavone FS, Rubart M, Sacconi L, Zaglia T & Mongillo M (2019). Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery. J Physiol 597, 3639-3656.
1. Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW & Kobilka BK (2007). Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol 176, 521-533.