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Editorial
. 2019 Aug;39(8):1501-1503.
doi: 10.1161/ATVBAHA.119.312965. Epub 2019 Jul 24.

Enigma of Inflammasome Activation by Kinases

Ying H Shen  1 , Jun-Ichi Abe  2
Affiliations
Editorial

Enigma of Inflammasome Activation by Kinases

Ying H Shen et al. Arterioscler Thromb Vasc Biol. 2019 Aug.
No abstract available

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Figures

Figure.
Figure.. ROS, kinases, and inflammasome activation
A number of kinsess can directly phosphorylate NLRP3 and ASC and activate inflammasome activation. Furthermore, ROS can activate NLRP3 activation via promoting TXNIP and NEK7 interaction with NLRP3. It is pssible that the ROS production induced by DAPKs and IRAK1 may contribute to NLRP3 activation initiated by these kinases activation. Lastly, MARK4 can bind to NLRP3 and activate it by driveing NLRP3 to the microtubule-organizing center. Please see the details in the text. TXNIP: thioredoxin-interacting protein (TXNIP), TRX: thioreoxin, NEK7: NIMA related kinase 7, CLIC: chloride intracellular channels, DAPK: Death associated proteik kinase, IRAK1: Interleukin 1 receptor associated kinase 1, PKA: Protein kinase A, PKD: Protein kinase D, Syk: Spleen associated tyrosine kinase, Pyk2: Proline-rich tyrosine kinase 2, PYD: Pyrin domain, CARD: Caspase activation and recruitment domain, LRR: Leucine-rich repeat, P2X7R: Purinergic Receptor P2X7.
See this image and copyright information in PMC

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