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Editorial
. 2019 Aug;39(8):1507-1509.
doi: 10.1161/ATVBAHA.119.312972. Epub 2019 Jul 24.

Application of Dynamic Contrast Enhanced Magnetic Resonance Imaging to Evaluate Angiogenic Response and Vascular Permeability

Mary C Wallingford  1   2 , Tomo Tarui  1 , Nirmala Jayaraman  1 , Gordon S Huggins  2 , Manjiri K Dighe  3
Affiliations
Editorial

Application of Dynamic Contrast Enhanced Magnetic Resonance Imaging to Evaluate Angiogenic Response and Vascular Permeability

Mary C Wallingford et al. Arterioscler Thromb Vasc Biol. 2019 Aug.
No abstract available

Keywords: Editorial; arterioles; gadolinium; mesoderm; trophoblasts.

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Figures

Figure.
Figure.. Graphical abstract on the study of TG2 and FXIII in decidual angiogenesis.
A, Cohen et al apply an innovative strategy involving phage display–mediated identification of substrate analogs, Gd-labeling of the analogs, and DCE-MRI to reveal new roles of TG2 and FXIII in decidual angiogenesis. These studies are complemented by CRISPR-mediated gene deletion, lentiviral overexpression, and histological analyses. B, The study presented by Cohen et al supports roles for TG2 and FXIII in both decidual vascular permeability and blood volume regulation following blastocyst attachment. Upper diagram: illustration of a subset of developmental events that occur in the uterus during implantation and early placentation. Lower images contain examples of the maternal-fetal interface at each developmental stage. Left: a blastocyst and adjacent ULE with trophectoderm in red, inner cell mass in green, and ULE in blue. Middle: the remodeling implantation site with decidua in green and ULE in red. Right: an implanted embryo with basal lamina in green, extraembryonic cells in white, and epiblast in red. DCE-MRI indicates dynamic contrast enhanced-MRI; De, decidua; ECM, extracellular matrix; Em, embryo; Gd, gadolinium; SA, substrate analogs; SpA, spiral arteries; and ULE, uterine luminal epithelium.
See this image and copyright information in PMC

Comment on

References

    1. Cohen G, Hadas R, Stefania R, Pagoto A, Ben-Dor S, Kohen F, Longo D, Elbaz M, Dekel N, Gershon E, Aime S, Neeman M. Magnetic resonance imaging reveals distinct roles for tissue transglutaminase and factor XIII in maternal angiogenesis during early mouse pregnancy. Arterioscler Thromb Vasc Biol. 2019;39:1602–1613. doi: 10.1161/ATVBAHA.119.312832 - DOI - PMC - PubMed
    1. Plaks V, Birnberg T, Berkutzki T, Sela S, BenYashar A, Kalchenko V, Mor G, Keshet E, Dekel N, Neeman M, Jung S. Uterine DCs are crucial for decidua formation during embryo implantation in mice. J Clin Invest. 2008;118:3954–3965. doi: 10.1172/JCI36682 - DOI - PMC - PubMed
    1. Plaks V, Kalchenko V, Dekel N, Neeman M. MRI analysis of angiogenesis during mouse embryo implantation. Magn Reson Med. 2006;55:1013–1022. doi: 10.1002/mrm.20881 - DOI - PubMed
    1. Plaks V, Gershon E, Zeisel A, Jacob-Hirsch J, Neeman M, Winterhager E, Rechavi G, Domany E, Dekel N. Blastocyst implantation failure relates to impaired translational machinery gene expression. Reproduction. 2014;148:87–98. doi: 10.1530/REP-13-0395 - DOI - PubMed
    1. Pulendran B, Smith JL, Caspary G, Brasel K, Pettit D, Maraskovsky E, Maliszewski CR. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci USA. 1999;96:1036–1041. doi: 10.1073/pnas.96.3.1036 - DOI - PMC - PubMed