Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Aug 7;14(8):1122-1124.
doi: 10.2215/CJN.07300619. Epub 2019 Jul 24.

Does Epitope Spreading Influence Responsiveness to Rituximab in PLA2R-Associated Membranous Nephropathy?

David J Salant  1
Affiliations
Editorial

Does Epitope Spreading Influence Responsiveness to Rituximab in PLA2R-Associated Membranous Nephropathy?

David J Salant. Clin J Am Soc Nephrol. .
No abstract available

Keywords: Epitopes; Glomerulonephritis, Membranous; PLA2R1 protein, human; Receptors, Phospholipase A2; autoantibody; epitope spreading; membranous nephropathy; phospholipase A2 receptor; rituximab.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Intra-molecular epitope spreading of the anti-phospholipase A2 receptor autoantibody reaction. The figure illustrates spreading of anti-PLA2R antibodies from a ubiquitous epitope in the cysteine-rich (CysR) domain to involve epitopes in the first and seventh C-type lectin domains (CTLD1 and CTLD7, respectively). FnII, fibronectin type 2 domain; ICD, intracellular domain.
See this image and copyright information in PMC

Comment on

  • High-Dose Rituximab and Early Remission in PLA2R1-Related Membranous Nephropathy.
    Seitz-Polski B, Dahan K, Debiec H, Rousseau A, Andreani M, Zaghrini C, Ticchioni M, Rosenthal A, Benzaken S, Bernard G, Lambeau G, Ronco P, Esnault VLM. Seitz-Polski B, et al. Clin J Am Soc Nephrol. 2019 Aug 7;14(8):1173-1182. doi: 10.2215/CJN.11791018. Epub 2019 Jul 24. Clin J Am Soc Nephrol. 2019. PMID: 31340979 Free PMC article. Clinical Trial.

References

    1. Seitz-Polski B, Dahan K, Debiec H, Rousseau A: High-dose rituximab induces faster and more complete remission of PLA2R1-related membranous nephropathy. Clin J Am Soc Nephrol 14: 1173–1182, 2019 - PMC - PubMed
    1. Didona D, Di Zenzo G: Humoral epitope spreading in autoimmune bullous diseases. Front Immunol 9: 779, 2018 - PMC - PubMed
    1. Shah P, Tramontano A, Makker SP: Intramolecular epitope spreading in Heymann nephritis. J Am Soc Nephrol 18: 3060–3066, 2007 - PubMed
    1. Fresquet M, Jowitt TA, Gummadova J, Collins R, O’Cualain R, McKenzie EA, Lennon R, Brenchley PE: Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy. J Am Soc Nephrol 26: 302–313, 2015 - PMC - PubMed
    1. Seitz-Polski B, Dolla G, Payré C, Girard CA, Polidori J, Zorzi K, Birgy-Barelli E, Jullien P, Courivaud C, Krummel T, Benzaken S, Bernard G, Burtey S, Mariat C, Esnault VL, Lambeau G: Epitope spreading of autoantibody response to PLA2R associates with poor prognosis in membranous nephropathy. J Am Soc Nephrol 27: 1517–1533, 2016 - PMC - PubMed