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. 2019 Jun 23:2019:6289478.
doi: 10.1155/2019/6289478. eCollection 2019.

Potential Association of Body Constitution with the Prognosis of IgA Nephropathy: A Long-Time Follow-Up of 203 Cases in China

Linchang Liu  1   2 , Zhiwei Yin  1 , Jiwei Ma  1 , Shuwei Duan  1 , Xiangmei Chen  1
Affiliations

Potential Association of Body Constitution with the Prognosis of IgA Nephropathy: A Long-Time Follow-Up of 203 Cases in China

Linchang Liu et al. Evid Based Complement Alternat Med. .

Abstract

Objective: This study investigated the association between body constitution (BC) and the prognosis of IgA nephropathy.

Methods: We analyzed 203 biopsy-diagnosed IgA nephropathy patients, who were followed up for (63.9±16.2) months. The participants' BC statuses were evaluated with the Constitution in Chinese Medicine Questionnaire; the relationships between clinical parameters and renal outcomes were analyzed by Cox regression.

Results: Patients were classified into chronic kidney disease stages with 43.4% in stage 1, 27.1% in stage 2, 26.1% in stage 3, 3.5% in stage 4, and none in stage 5. Qi-deficiency BC type was the most common BC type in IgA nephropathy patients. In univariate analysis, proteinuria of more than 1g/d, hypertension, renal impairment (estimated glomerular filtration rate <60 mL/min), hypoproteinemia, hyperuricemia, Yang-deficiency BC, and blood-stasis BC were associated with poor prognosis. Multivariate analysis identified that hypertension (hazard ratios (HR) 3.5, P=0.009), renal impairment (HR 5.8, P<0.001), Yang-deficiency BC (HR 2.3, P=0.041), and blood-stasis BC (HR 2.5, P=0.017) were independent predictors of unfavorable renal outcomes.

Conclusions: Most patients of IgA nephropathy were biopsied at an early stage. Yang-deficiency BC and blood-stasis BC at biopsy were most closely associated with the worse prognosis of IgA nephropathy along with hypertension and renal impairment.

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References

    1. Lin J. S., Chen L. L., Lin J. D., et al. Bcqs: a body constitution questionnaire to assess Yin-Xu. Part II: evaluation of reliability and validity. Forsch Komplementmed. 2012;19(6):285–292. - PubMed
    1. Wang J., Wang Q., Li L., et al. Phlegm-dampness constitution: genomics, susceptibility, adjustment and treatment with traditional Chinese medicine. American Journal of Chinese Medicine. 2013;41(2):253–262. doi: 10.1142/s0192415x13500183. - DOI - PubMed
    1. Liu X., Liu L., Chen P., et al. Clinical trials of traditional Chinese medicine in the treatment of diabetic nephropathy—a systematic review based on a subgroup analysis. Journal of Ethnopharmacology. 2014;151(2):810–819. doi: 10.1016/j.jep.2013.11.028. - DOI - PubMed
    1. Cen Y., Leung R. K.-K., Zhang F., et al. The association between Yang-Deficient Constitution and clinical outcome of highly active antiretroviral therapy on people living with HIV. Evidence-Based Complementary and Alternative Medicine. 2013;2013:9.201857 - PMC - PubMed
    1. Huang K.-C., Chen C.-C., Su Y.-C., et al. The relationship between stasis-stagnation constitution and peripheral arterial disease in patients with type 2 diabetes. Evidence-Based Complementary and Alternative Medicine. 2014;2014:6. doi: 10.1155/2014/903798.903798 - DOI - PMC - PubMed

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