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. 2019 Jun 1;9(3):267-278.
doi: 10.31661/jbpe.v9i3Jun.655. eCollection 2019 Jun.

Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy

Mesbahi A  1   2   3 , Rasouli N  1   2 , Mohammadzadeh M  3 , Nasiri Motlagh B  3   4 , Ozan Tekin H  5
Affiliations

Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy

Mesbahi A et al. J Biomed Phys Eng. .

Abstract

Purpose: In the current study, using different radiobiological models, tumor control probability (TCP) and normal tissue complication probability (NTCP) of radiotherapy plans were calculated for three-dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) of prostate cancer.

Methods and materials: 10 prostate plans were randomly selected among patients undergoing radiation therapy of prostate cancer. For each patient, 3D-CRT and IMRT plans were designed to deliver, on average 76 Gy and 82 Gy to planning target volume, respectively. Using different radiobiological models including Poisson, equivalent uniform dose (EUD) and Lyman-Kutcher-Burman (LKB), TCP and NTCP were calculated for prostate and critical organs including bladder, rectum and femoral heads.

Results: IMRT plans provided significantly lower NTCP for bladder, rectum and femoral heads using LKB and EUD models (p-value <0.05). The EUD-calculated TCP for prostate cancer revealed no considerable improvement for IMRT plans relative to 3D-CRT plans. However, the TCPs calculated by Poisson model were dependent on α/β, and higher TCP for IMRT relative to 3D-CRT was seen for α/β higher than 5.

Conclusion: It can be concluded that IMRT plans were superior to 3D-CRT plans in terms of estimated NTCP for studied critical organs. On the other hand, different mathematical models provided different quantitative outcome for TCP of prostate cancer plans. More clinical studies are suggested to confirm the accuracy of studied radiobiological models.

Keywords: 3D-CRT, Radiation Therapy; IMRT; Normal Tissue Complication Probability; Prostate Cancer; Radiobiological Modelling; Tumor Control Probability.

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Figures

Figure1
Figure1
dose distributions and dose volume histograms of 3D-CRT and IMRT plans for patient #3. (A) dose distribution for 3D-CRT. (B)dose distribution for IMRT.(C) dose-volume histogram for 3D-CRT. (D) dose-volume histogram for IMRT.
See this image and copyright information in PMC

References

    1. Jensen I, Carl J, Lund B, Larsen E H, Nielsen J. Radiobiological impact of reduced margins and treatment technique for prostate cancer in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP) Med Dosim. 2011;36:130–7. doi: 10.1016/j.meddos.2010.02.004. - DOI - PubMed
    1. Koontz B F, Das S, Temple K, Bynum S, Catalano S, Koontz J I, et al. Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy. Med Dosim. 2009;34:256–60. doi: 10.1016/j.meddos.2008.10.005. - DOI - PubMed
    1. Luxton G, Hancock S L, Boyer A L. Dosimetry and radiobiologic model comparison of IMRT and 3D conformal radiotherapy in treatment of carcinoma of the prostate. Int J Radiat Oncol Biol Phys. 2004;59:267–84. doi: 10.1016/j.ijrobp.2004.01.024. - DOI - PubMed
    1. Nahum A E, Uzan J. (Radio)biological optimization of external-beam radiotherapy. Comput Math Methods Med. 2012;2012:329214. [ PMC Free Article] - PMC - PubMed
    1. Rana S, Cheng C. Radiobiological impact of planning techniques for prostate cancer in terms of tumor control probability and normal tissue complication probability. Ann Med Health Sci Res. 2014;4:167–72. doi: 10.4103/2141-9248.129023. [ PMC Free Article] - DOI - PMC - PubMed

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