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. 1988 Apr;7(2):291-2.
doi: 10.1007/BF01963104.

Outer membrane protein serosubtyping of Neisseria meningitidis

J T Poolman  1 , H Abdillahi
Affiliations

Outer membrane protein serosubtyping of Neisseria meningitidis

J T Poolman et al. Eur J Clin Microbiol Infect Dis. 1988 Apr.

Abstract

A system for typing Neisseria meningitidis has been developed which uses monoclonal antibodies against two separate classes of outer membrane proteins (class 1 and class 2/3) in addition to capsular polysaccharide serogrouping. It was shown that class 1 outer membrane protein subtypes are common to meningococcal reference strains of different serotypes. Application of the system to 50 group B meningococcal patient isolates revealed that 75% could be categorized as class 1 subtypes. The typing system has potential usefulness in epidemiological surveillance and vaccine development.

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References

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