Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep 1;5(9):1362-1364.
doi: 10.1001/jamaoncol.2019.2203.

Association of Germline BRCA2 Mutations With the Risk of Pediatric or Adolescent Non-Hodgkin Lymphoma

Zhaoming Wang  1   2 , Carmen L Wilson  1 , Gregory T Armstrong  1 , Melissa M Hudson  1   3 , Jinghui Zhang  2 , Kim E Nichols  3 , Leslie L Robison  1
Affiliations

Association of Germline BRCA2 Mutations With the Risk of Pediatric or Adolescent Non-Hodgkin Lymphoma

Zhaoming Wang et al. JAMA Oncol. .

Abstract

This study uses whole-genome sequencing to examine whether survivors of childhood lymphoma who are carriers of BRCA2 gene mutation have a greater likelihood of developing adult-onset cancers.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: None.

References

    1. Wang Z, Wilson CL, Easton J, et al. . Genetic risk for subsequent neoplasms among long-term survivors of childhood cancer. J Clin Oncol. 2018;36(20):2078-2087. doi:10.1200/JCO.2018.77.8589 - DOI - PMC - PubMed
    1. Hudson MM, Ehrhardt MJ, Bhakta N, et al. . Approach for classification and severity grading of long-term and late-onset health events among childhood cancer survivors in the St. Jude lifetime cohort. Cancer Epidemiol Biomarkers Prev. 2017;26(5):666-674. doi:10.1158/1055-9965.EPI-16-0812 - DOI - PMC - PubMed
    1. Robison LL, Armstrong GT, Boice JD, et al. . The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. J Clin Oncol. 2009;27(14):2308-2318. doi:10.1200/JCO.2009.22.3339 - DOI - PMC - PubMed
    1. Zhang J, Walsh MF, Wu G, et al. . Germline mutations in predisposition genes in pediatric cancer. N Engl J Med. 2015;373(24):2336-2346. doi:10.1056/NEJMoa1508054 - DOI - PMC - PubMed
    1. Kalia SS, Adelman K, Bale SJ, et al. . Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics. Genet Med. 2017;19(2):249-255. doi:10.1038/gim.2016.190 - DOI - PubMed