PVA/SA/TiO2-CUR patch for enhanced wound healing application: In vitro and in vivo analysis

Abstract

Wound healing is a complex multistep process. Wound healing materials should have good antibacterial activity against wound infection causing microbes. Curcumin has effective antimicrobial activity, anti-inflammatory and antioxidant property. Titanium dioxide (TiO₂) is a biocompatible, nontoxic material used for many biomedical applications. The Usage of curcumin tagged TiO₂ nanoparticles for wound healing activity is promising due to the properties of both curcumin and TiO₂. We have synthesized curcumin tagged TiO₂ nanoparticles. The synthesized materials are characterized with XRD, FTIR and TEM. TiO₂-Cur nanocomposite was incorporated into poly vinyl alcohol (PVA) and sodium alginate (SA) patch. The PVA/SA/TiO₂-Cur patch was prepared by gel casting method. Antibacterial efficiency of PVA/SA/TiO₂-Cur patch was analyzed. Further, in vivo studies conducted on Wister rats confirmed the enhanced wound healing property of the PVA/SA/TiO₂-Cur patch. Our results suggest that this could be an ideal biomaterial for wound dressing applications.

Keywords: Antibacterial activity; Collagen; Curcumin; PVA/SA/TiO(2)-Cur; Wistar rats; Wound healing.