Induction of labor and postpartum blood loss

doi:10.1186/s12884-019-2410-8

. 2019 Jul 25;19(1):265.

doi: 10.1186/s12884-019-2410-8.

Induction of labor and postpartum blood loss

Romana Brun¹, Emilian Spoerri², Leonhard Schäffer³, Roland Zimmermann¹, Christian Haslinger⁴

Affiliations

¹ Division of Obstetrics, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.
² University of Zurich, Zurich, Switzerland.
³ Division of Obstetrics, Kantonsspital Baden, Baden, Switzerland.
⁴ Division of Obstetrics, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland. christian.haslinger@usz.ch.

PMID: 31345178
PMCID: PMC6659310
DOI: 10.1186/s12884-019-2410-8

Induction of labor and postpartum blood loss

Romana Brun et al. BMC Pregnancy Childbirth. 2019.

. 2019 Jul 25;19(1):265.

doi: 10.1186/s12884-019-2410-8.

Authors

Romana Brun¹, Emilian Spoerri², Leonhard Schäffer³, Roland Zimmermann¹, Christian Haslinger⁴

Affiliations

¹ Division of Obstetrics, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.
² University of Zurich, Zurich, Switzerland.
³ Division of Obstetrics, Kantonsspital Baden, Baden, Switzerland.
⁴ Division of Obstetrics, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland. christian.haslinger@usz.ch.

PMID: 31345178
PMCID: PMC6659310
DOI: 10.1186/s12884-019-2410-8

Abstract

Background: To analyze blood loss after delivery in women with induction of labor compared to women with spontaneous onset of labor.

Methods: In this secondary analysis of a prospective cohort study investigating postpartum hemorrhage, 965 deliveries were analyzed including 380 women with induction of labor (39%) between 2015 and 2016. Primary outcome parameters were rate of postpartum hemorrhage, estimated blood loss and post-partum decrease in hemoglobin.

Results: Rates of postpartum hemorrhage and estimated blood loss were not significantly different in women with induction of labor. Women with induction of labor had a significantly reduced decrease in hemoglobin after delivery. In the multivariate linear regression analysis, induction of labor remained associated with reduced decrease in hemoglobin. Secondary maternal and neonatal outcomes were unaffected.

Conclusions: Induction of labor is not associated with increased blood loss after delivery and should not be regarded as a risk factor for postpartum hemorrhage.

Keywords: Delta hemoglobin; Induction of labor; Postpartum blood loss; Postpartum hemorrhage; Spontaneous onset of labor.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Cited by

Retrospective Analysis of the Factors Affecting the Induction of Childbirth in 4350 Women from a Single Center in Warsaw, Poland.
Bączek G, Rzońca E, Rzońca P, Rychlewicz S, Budner M, Bień A. Bączek G, et al. Int J Environ Res Public Health. 2022 Aug 3;19(15):9540. doi: 10.3390/ijerph19159540. Int J Environ Res Public Health. 2022. PMID: 35954893 Free PMC article.
Timing of Prostin E2 Administration After Poor Response to Propess: Impact on Induction-to-Birth Interval and Maternal/Neonatal Outcomes.
Ting NS, Wei YC, Ding DC. Ting NS, et al. Medicina (Kaunas). 2025 Jul 10;61(7):1255. doi: 10.3390/medicina61071255. Medicina (Kaunas). 2025. PMID: 40731884 Free PMC article.

References

1. WHO Guidelines Review Committee. WHO Guidelines Approved by the Guidelines Review Committee. In: WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage. edn. Geneva: World Health OrganizationWorld Health Organization; 2012.
1. Solomon C, Collis RE, Collins PW. Haemostatic monitoring during postpartum haemorrhage and implications for management. Br J Anaesth. 2012;109(6):851–863. doi: 10.1093/bja/aes361. - DOI - PMC - PubMed
1. Mousa HA, Blum J, Abou El Senoun G, Shakur H, Alfirevic Z. Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2014(2). 10.1002/14651858.CD003249.pub3. - PMC - PubMed
1. Oyelese Y, Ananth CV. Postpartum hemorrhage: epidemiology, risk factors, and causes. Clin Obstet Gynecol. 2010;53(1):147–156. doi: 10.1097/GRF.0b013e3181cc406d. - DOI - PubMed
1. Nicholson JM, Kellar LC, Henning GF, Waheed A, Colon-Gonzalez M, Ural S. The association between the regular use of preventive labour induction and improved term birth outcomes: findings of a systematic review and meta-analysis. BJOG. 2015;122(6):773–784. doi: 10.1111/1471-0528.13301. - DOI - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- ClinicalTrials.gov

[1] WHO Guidelines Review Committee. WHO Guidelines Approved by the Guidelines Review Committee. In: WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage. edn. Geneva: World Health OrganizationWorld Health Organization; 2012.

[2] WHO Guidelines Review Committee. WHO Guidelines Approved by the Guidelines Review Committee. In: WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage. edn. Geneva: World Health OrganizationWorld Health Organization; 2012.

[3] Solomon C, Collis RE, Collins PW. Haemostatic monitoring during postpartum haemorrhage and implications for management. Br J Anaesth. 2012;109(6):851–863. doi: 10.1093/bja/aes361. - DOI - PMC - PubMed

[4] Solomon C, Collis RE, Collins PW. Haemostatic monitoring during postpartum haemorrhage and implications for management. Br J Anaesth. 2012;109(6):851–863. doi: 10.1093/bja/aes361. - DOI - PMC - PubMed

[5] Mousa HA, Blum J, Abou El Senoun G, Shakur H, Alfirevic Z. Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2014(2). 10.1002/14651858.CD003249.pub3. - PMC - PubMed

[6] Mousa HA, Blum J, Abou El Senoun G, Shakur H, Alfirevic Z. Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2014(2). 10.1002/14651858.CD003249.pub3. - PMC - PubMed

[7] Oyelese Y, Ananth CV. Postpartum hemorrhage: epidemiology, risk factors, and causes. Clin Obstet Gynecol. 2010;53(1):147–156. doi: 10.1097/GRF.0b013e3181cc406d. - DOI - PubMed

[8] Oyelese Y, Ananth CV. Postpartum hemorrhage: epidemiology, risk factors, and causes. Clin Obstet Gynecol. 2010;53(1):147–156. doi: 10.1097/GRF.0b013e3181cc406d. - DOI - PubMed

[9] Nicholson JM, Kellar LC, Henning GF, Waheed A, Colon-Gonzalez M, Ural S. The association between the regular use of preventive labour induction and improved term birth outcomes: findings of a systematic review and meta-analysis. BJOG. 2015;122(6):773–784. doi: 10.1111/1471-0528.13301. - DOI - PubMed

[10] Nicholson JM, Kellar LC, Henning GF, Waheed A, Colon-Gonzalez M, Ural S. The association between the regular use of preventive labour induction and improved term birth outcomes: findings of a systematic review and meta-analysis. BJOG. 2015;122(6):773–784. doi: 10.1111/1471-0528.13301. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Induction of labor and postpartum blood loss

Affiliations

Induction of labor and postpartum blood loss

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Similar articles

Cited by

References

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Medical