Mass Spectrometry-Based Tissue Imaging of Small Molecules

Carly N Ferguson¹, Joseph W M Fowler¹, Jonathan F Waxer¹, Richard A Gatti^{2

3}, Joseph A Loo^{4

5}

Affiliations

¹ Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA.
² Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
³ Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
⁴ Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA. jloo@chem.ucla.edu.
⁵ Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA. jloo@chem.ucla.edu.

PMID: 31347043
DOI: 10.1007/978-3-030-15950-4_5

Review

Mass Spectrometry-Based Tissue Imaging of Small Molecules

Carly N Ferguson et al. Adv Exp Med Biol. 2019.

. 2019:1140:99-109.

doi: 10.1007/978-3-030-15950-4_5.

Authors

Carly N Ferguson¹, Joseph W M Fowler¹, Jonathan F Waxer¹, Richard A Gatti^{2

3}, Joseph A Loo^{4

5}

Affiliations

¹ Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA.
² Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
³ Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
⁴ Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA. jloo@chem.ucla.edu.
⁵ Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA. jloo@chem.ucla.edu.

PMID: 31347043
DOI: 10.1007/978-3-030-15950-4_5

Abstract

Mass spectrometry imaging (MSI) of tissue samples is a promising analytical tool that has quickly become associated with biomedical and pharmacokinetic studies. It eliminates several labor-intensive protocols associated with more classical imaging techniques, and provides accurate, histological data at a rapid pace. Because mass spectrometry is used as the readout, MSI can be applied to almost any molecule, especially those that are biologically relevant. Many examples of its utility in the study of peptides and proteins have been reported; here we discuss its value in the mass range of small molecules. We explore its success and potential in the analysis of lipids, medicinals, and metal-based compounds by featuring representative studies from mass spectrometry imaging laboratories around the globe.

Keywords: Drug compounds; Lipids; Mass spectrometry tissue imaging; Nanoparticles; Small molecules.

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Mass Spectrometry-Based Tissue Imaging of Small Molecules

Affiliations

Mass Spectrometry-Based Tissue Imaging of Small Molecules

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical