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. 2020 Mar;37(1):11-18.
doi: 10.1111/ger.12431. Epub 2019 Jul 26.

Systemic inflammatory impact of periodontitis on cognitive impairment

José Antonio Gil Montoya  1 , Rocío Barrios  1 , Inés Sanchez-Lara  1 , Pablo Ramos  1 , Cristobal Carnero  2 , Francisco Fornieles  3 , Juan Montes  2 , Soraya Santana  4 , Juan de Dios Luna  1 , Miguel Angel Gonzalez-Moles  1
Affiliations

Systemic inflammatory impact of periodontitis on cognitive impairment

José Antonio Gil Montoya et al. Gerodontology. 2020 Mar.

Abstract

Objectives: The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment.

Methods: We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques.

Results: At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding.

Conclusions: Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment.

Keywords: Alzheimer’s disease; biomarkers; cytokines; inflammation; periodontal disease.

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References

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