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Observational Study
. 2019 Jul;98(30):e16603.
doi: 10.1097/MD.0000000000016603.

Thalamic and cerebellar hypoperfusion in single photon emission computed tomography may differentiate multiple system atrophy and progressive supranuclear palsy

Piotr Alster  1 , Michał Nieciecki  2 , Dariusz M Koziorowski  1 , Andrzej Cacko  3 , Ingeborga Charzyńska  4 , Leszek Królicki  4   5 , Andrzej Friedman  1
Affiliations
Observational Study

Thalamic and cerebellar hypoperfusion in single photon emission computed tomography may differentiate multiple system atrophy and progressive supranuclear palsy

Piotr Alster et al. Medicine (Baltimore). 2019 Jul.

Abstract

Neuroimaging in the context of examining atypical parkinsonian tauopathies is an evolving matter. Positron emission tomography and single photon emission computed tomography (SPECT) bring tools, which may be reasonable in supplementary examination, however, cannot be interpreted as a criterion standard for correct diagnosis. The aim of this observational study was to assess the differentiating potential of perfusion SPECT in 3 types of atypical parkinsonisms: multiple system atrophy parkinsonian type (MSA-P), corticobasal syndrome (CBS), and progressive supranuclear palsy (PSP). The study was carried out using the comparison of standard deviations of perfusion in patients from these 3 groups. Data obtained from 10 patients with clinical diagnosis MSA-P, 14 patients with CBS and 21 patients with PSP, which were analyzed using Tukey honest significant difference post-hoc test, revealed significant differences of perfusion P < .05 between MSA-P and PSP within the cerebellum and thalamus. No significant differences between CBS and PSP were observed.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
A patient with clinical diagnosis of progressive supranuclear palsy (PSP). Hypoperfusion in the thalami bilaterally.
Figure 2
Figure 2
A patient with clinical diagnosis of corticobasal syndrome (CBS). Hypoperfusion within the left thalamus.
Figure 3
Figure 3
A patient with clinical diagnosis of multiple system atrophy (MSA). Hypoperfusion in the cerebellum.
See this image and copyright information in PMC

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