Survival and specific outcome of sickle cell disease patients after renal transplantation

Christel Gérardin^{1

2}, Anissa Moktefi^{2

3}, Cécile Couchoud⁴, Alyette Duquesne⁵, Nacera Ouali⁶, Philippe Gataut⁷, Alexandre Karras⁸, Dany Anglicheau^{9

10}, Carmen Lefaucheur¹¹, Lucile Figueres¹², Laetitia Albano¹³, Arnaud Lionet¹⁴, Marine Novion¹⁵, Marie-Julia Ziliotis¹⁶, Magali Louis¹⁷, Arnaud Del Bello¹⁸, Marie Matignon^{1

2}, Karine Dahan¹⁹, Anoosha Habibi^{20

21}, Frederic Galacteros^{20

21}, Pablo Bartolucci^{20

21}, Philippe Grimbert^{1

2}, Vincent Audard^{1

2}

Affiliations

¹ AP-HP (Assistance Publique-Hôpitaux de Paris), Department of Nephrology and Transplantation, Rare French Disease Centre "Idiopathic Nephrotic syndrome", Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
² Inserm U955, Team 21, DHU VIC, Paris-Est University, Créteil, France.
³ AP-HP, Department of Pathology, Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
⁴ REIN registry. Agence de la Biomédecine, Saint Denis La Plaine, France.
⁵ Department of Nephrology, André Grégoire Hospital, Montreuil, France.
⁶ AP-HP, Department of Nephrology and Transplantation, Tenon Hospital, Sorbonne University, Paris, France.
⁷ Department of Nephrology, Hypertension, Transplantation and Dialysis Bretonneau Hospital, Centre Hospitalo Universitaire (CHU) Tours, Tours, France.
⁸ AP-HP, Department of Nephrology, Européen Gorges Pompidou Hospital, Paris, France.
⁹ AP-HP, Department of Nephrology and Kidney Transplantation, Necker Hospital, Paris, France.
¹⁰ Descartes University, Réseau Thématique de Recherche et de Soins Centaure, LabEx Transplantex, Paris, France.
¹¹ AP-HP, Department of Nephrology and Transplantation, Saint-Louis Hospital, Paris, France.
¹² Institute of Transplantation Urology and Nephrology (ITUN), CHU Nantes, Nantes University, Nantes, France.
¹³ Department of Nephrology, Dialysis, and Renal Transplantation, CHU Nice, Nice, France.
¹⁴ Department of Nephrology, Transplantation and Dialysis, Huriez University Hospital, Lille, France.
¹⁵ Department of Nephrology, Transplantation, Dialysis and Apheresis, Pellegrin University Hospital, Bordeaux, France.
¹⁶ Department of Nephrology, Dialysis, and Renal Transplantation, CHU Besançon, Besançon, France.
¹⁷ Transplant Federation, François Mitterrand University Hospital, CHU Dijon, Dijon, France.
¹⁸ Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
¹⁹ AP-HP, Department of Nephrology and Dialysis, Tenon Hospital, Sorbonne University, Paris, France.
²⁰ AP-HP, Sickle Cell Referral Centre, Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
²¹ Inserm U955, Team 2, DHU A-TVB, Paris-Est University, Créteil, France.

PMID: 31348518
DOI: 10.1111/bjh.16113

Observational Study

Survival and specific outcome of sickle cell disease patients after renal transplantation

Christel Gérardin et al. Br J Haematol. 2019 Dec.

. 2019 Dec;187(5):676-680.

doi: 10.1111/bjh.16113. Epub 2019 Jul 26.

Authors

Affiliations

¹ AP-HP (Assistance Publique-Hôpitaux de Paris), Department of Nephrology and Transplantation, Rare French Disease Centre "Idiopathic Nephrotic syndrome", Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
² Inserm U955, Team 21, DHU VIC, Paris-Est University, Créteil, France.
³ AP-HP, Department of Pathology, Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
⁴ REIN registry. Agence de la Biomédecine, Saint Denis La Plaine, France.
⁵ Department of Nephrology, André Grégoire Hospital, Montreuil, France.
⁶ AP-HP, Department of Nephrology and Transplantation, Tenon Hospital, Sorbonne University, Paris, France.
⁷ Department of Nephrology, Hypertension, Transplantation and Dialysis Bretonneau Hospital, Centre Hospitalo Universitaire (CHU) Tours, Tours, France.
⁸ AP-HP, Department of Nephrology, Européen Gorges Pompidou Hospital, Paris, France.
⁹ AP-HP, Department of Nephrology and Kidney Transplantation, Necker Hospital, Paris, France.
¹⁰ Descartes University, Réseau Thématique de Recherche et de Soins Centaure, LabEx Transplantex, Paris, France.
¹¹ AP-HP, Department of Nephrology and Transplantation, Saint-Louis Hospital, Paris, France.
¹² Institute of Transplantation Urology and Nephrology (ITUN), CHU Nantes, Nantes University, Nantes, France.
¹³ Department of Nephrology, Dialysis, and Renal Transplantation, CHU Nice, Nice, France.
¹⁴ Department of Nephrology, Transplantation and Dialysis, Huriez University Hospital, Lille, France.
¹⁵ Department of Nephrology, Transplantation, Dialysis and Apheresis, Pellegrin University Hospital, Bordeaux, France.
¹⁶ Department of Nephrology, Dialysis, and Renal Transplantation, CHU Besançon, Besançon, France.
¹⁷ Transplant Federation, François Mitterrand University Hospital, CHU Dijon, Dijon, France.
¹⁸ Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
¹⁹ AP-HP, Department of Nephrology and Dialysis, Tenon Hospital, Sorbonne University, Paris, France.
²⁰ AP-HP, Sickle Cell Referral Centre, Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
²¹ Inserm U955, Team 2, DHU A-TVB, Paris-Est University, Créteil, France.

PMID: 31348518
DOI: 10.1111/bjh.16113

Abstract

The prognosis of sickle cell disease (SCD) patients who need dialysis is poor, but experience with kidney transplantation is limited. This study assessed the characteristics of 36 SCD patients undergoing renal transplantation. Immediate post-surgical complications occurred in 25% of cases. Cytomegalovirus and bacterial infections were frequently observed. Twelve patients died after a median follow-up period of 17·4 months. Overall patient survival was significantly lower in SCD than in the control group without significant difference for overall death-censored graft survival. Our data suggest that renal transplantation should be systematically considered in SCD patients with end-stage renal disease.

Keywords: infections; patient survival; renal transplantation; sickle cell disease.

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References

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Survival and specific outcome of sickle cell disease patients after renal transplantation

Affiliations

Survival and specific outcome of sickle cell disease patients after renal transplantation

Authors

Affiliations

Abstract

References

Publication types

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LinkOut - more resources

Full Text Sources

Medical