Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;82(3):743-746.
doi: 10.1016/j.jaad.2019.07.049. Epub 2019 Jul 23.

Prognostic implications of co-occurring dermatologic and gastrointestinal toxicity from immune checkpoint inhibition therapy for advanced malignancies: A retrospective cohort study

Affiliations

Prognostic implications of co-occurring dermatologic and gastrointestinal toxicity from immune checkpoint inhibition therapy for advanced malignancies: A retrospective cohort study

Gabriel E Molina et al. J Am Acad Dermatol. 2020 Mar.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Progression-Free Survival and Overall Survival in ICI-Induced Colitis Patients with and without Rash
A, Kaplan-Meier survival curves for progression-free survival (PFS) show that patients who developed both ICI-induced rash and colitis (cases [dashed line]) had significantly longer PFS than patients who developed isolated colitis (controls [solid line]) (P = 0.001). B, Kaplan-Meier survival curves for overall survival (OS) demonstrate significantly prolonged OS among patients with co-occurring ICI-induced rash and colitis (cases [dashed line]), compared to patients with colitis alone (controls [solid line]) (P = 0.018).

References

    1. Khoja L, Day D, Wei-Wu Chen T, et al. Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review. Ann Oncol. 2017;28(1):2377–2385. - PubMed
    1. Das KM, Vecchi M, Sakamaki S. A shared and unique epitope(s) on human colon, skin, and biliary epithelium detected by a monoclonal antibody. Gastroenterology. 1990;98(2):464. - PubMed
    1. Orchard TR, Chua CN, Ahmad T, et al. Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. Gastroenterology. 2002;123(3):714–718. - PubMed
    1. Min Lee CK, Li S, Tran DC, et al. Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: a retrospective case-control study. J Am Acad Dermatol. 2018;79(6):1047–1052. - PMC - PubMed
    1. Weber JS, Hodi FS, Wolchok JD, et al. Safety profile of nivolumab monotherapy: a pooled analysis of patients with advanced melanoma. J Clin Oncol. 2017;35(7):785–792. - PubMed