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. 2019 Sep;8(11):5373-5385.
doi: 10.1002/cam4.2017. Epub 2019 Jul 27.

The prevalence, trends, and geographical distribution of human papillomavirus infection in China: The pooled analysis of 1.7 million women

Bo Zhu  1 , Yunyong Liu  1 , Tingting Zuo  1 , Xiaoli Cui  2 , Mengdan Li  1 , Jing Zhang  2 , Huihui Yu  1 , Haozhe Piao  1
Affiliations

The prevalence, trends, and geographical distribution of human papillomavirus infection in China: The pooled analysis of 1.7 million women

Bo Zhu et al. Cancer Med. 2019 Sep.

Abstract

Human papillomavirus (HPV) infection which continues to be the most common sexually transmitted disease, has been identified as a major risk factor for cervical cancer. Therefore, it is very important to understand and grasp the distribution of HPV in Chinese population, and make the foundation for the development of cervical cancer vaccine in China. An extensive search strategy was conducted in multiple literature databases. All retrieved studies were screened by October 31, 2018. The prevalence of HPV infection was analyzed using random effects model. A total of 68 studies satisfied the inclusion criteria for our study. The national overall prevalence of HPV infection was 15.54% (95% CI: 13.83%-17.24%). we also performed subgroup analysis by age, geographic location, level of economic development, HPV assay method, and type of HPV infection. The top 5 common HPV types detected in general population, were HPV 16 (3.52%, 95% CI: 3.18%-3.86%), 52 (2.20%, 95% CI: 1.93%-2.46%), 58 (2.10%, 95% CI: 1.88%-2.32%), 18 (1.20%, 95% CI: 1.05%-1.35%), and 33 (1.02%, 95% CI: 0.89%-1.14%). Except for the higher prevalence of HPV infection in 2009 and 2010, the prevalence of HPV infection in other years changed little, ranged from 13.2% to 17.4%. HPV type in Chinese women was quite distinctive. HPV infection played a critical role in the occurrence of cervical cancer, understanding the distribution of HPV type and performing the HPV type testing had important clinical value for colposcopy referral and increasing the detection rate. Therefore, our findings could provide evidence for cervical cancer screening and vaccine, in order to reduce the burden of cervical cancer.

Keywords: China; HPV; distribution; general population.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
The flow chart of screening process in our meta‐analysis
Figure 2
Figure 2
The number of studies, the sample size, and the prevalence on Human papillomavirus (HPV) infection in each province of China
Figure 3
Figure 3
The time trend of Human papillomavirus (HPV) infection between 2003 and 2016
See this image and copyright information in PMC

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