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. 2019 Jul 27;20(1):461.
doi: 10.1186/s13063-019-3544-8.

Minimally invasive non-surgical vs. surgical approach for periodontal intrabony defects: a randomised controlled trial

L Nibali  1   2 , V Koidou  3 , S Salomone  3 , T Hamborg  4 , R Allaker  3 , R Ezra  3 , L Zou  3 , G Tsakos  5 , N Gkranias  3 , N Donos  3
Affiliations

Minimally invasive non-surgical vs. surgical approach for periodontal intrabony defects: a randomised controlled trial

L Nibali et al. Trials. .

Abstract

Background: Periodontal intrabony defects are usually treated surgically with the aim of increasing attachment and bone levels and reducing risk of progression. However, recent studies have suggested that a minimally invasive non-surgical therapy (MINST) leads to considerable clinical and radiographic defect depth reductions in intrabony defects. The aim of this study is to compare the efficacy of a modified MINST approach with a surgical approach (modified minimally invasive surgical therapy, M-MIST) for the treatment of intrabony defects.

Methods: This is a parallel-group, single-centre, examiner-blind non-inferiority randomised controlled trial with a sample size of 66 patients. Inclusion criteria are age 25-70, diagnosis of periodontitis stage III or IV (grades A to C), presence of ≥ 1 'intrabony defect' with probing pocket depth (PPD) > 5 mm and intrabony defect depth ≥ 3 mm. Smokers and patients who received previous periodontal treatment to the study site within the last 12 months will be excluded. Patients will be randomly assigned to either the modified MINST or the M-MIST protocol and will be assessed up to 15 months following initial therapy. The primary outcome of the study is radiographic intrabony defect depth change at 15 months follow-up. Secondary outcomes are PPD and clinical attachment level change, inflammatory markers and growth factors in gingival crevicular fluid, bacterial detection, gingival inflammation and healing (as measured by geometric thermal camera imaging in a subset of 10 test and 10 control patients) and patient-reported outcomes.

Discussion: This study will produce evidence about the clinical efficacy and potential applicability of a modified MINST protocol for the treatment of periodontal intrabony defects, as a less invasive alternative to the use of surgical procedures.

Trial registration: ClinicalTrials.gov, NCT03797807. Registered on 9 January 2019.

Keywords: Bone; Intrabony defect; Minimally invasive; Periodontitis; Quality of life.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of study plan and visits
Fig. 2
Fig. 2
CONSORT flowchart
See this image and copyright information in PMC

References

    1. Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045–1053. doi: 10.1177/0022034514552491. - DOI - PMC - PubMed
    1. Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Clin Periodontol. 2018;45 Suppl 20:S149–S161. doi: 10.1111/jcpe.12945. - DOI - PubMed
    1. Papapanou PN, Tonetti MS. Diagnosis and epidemiology of periodontal osseous lesions. Periodontology 2000. 2000;22:8–21. doi: 10.1034/j.1600-0757.2000.2220102.x. - DOI - PubMed
    1. Heitz-Mayfield LJ, Lang NP. Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontol 2000. 2013;62(1):218–231. doi: 10.1111/prd.12008. - DOI - PubMed
    1. Claffey N, Egelberg J. Clinical indicators of probing attachment loss following initial periodontal treatment in advanced periodontitis patients. J Clin Periodontol. 1995;22(9):690–696. doi: 10.1111/j.1600-051X.1995.tb00828.x. - DOI - PubMed

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