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. 2019 Nov;38(11):3211-3215.
doi: 10.1007/s10067-019-04682-3. Epub 2019 Jul 27.

The effect of lupus disease on the pregnant women and embryos: a retrospective study from 2010 to 2014

Elham Rajaei  1 , Nahid Shahbazian  2 , Hadi Rezaeeyan  3 , Amal Kia Mohammadi  1 , Saeed Hesam  4 , Zeinab Deris Zayeri  5
Affiliations

The effect of lupus disease on the pregnant women and embryos: a retrospective study from 2010 to 2014

Elham Rajaei et al. Clin Rheumatol. 2019 Nov.

Abstract

Background and aims: Pregnancy in women with systemic lupus erythematosus (SLE) is one of the challenges of recent studies. Women should prevent the onset of relapses with medications before and after pregnancy, and on the other hand, the effect of these medicines considers the health and development of the fetus. In this retrospective study, the effects of anti-phospholipid syndrome and the use of common drugs such as methotrexate, cyclosporine, and azathioprine and their side effects on maternal health and ultimately the development of the fetus have been investigated.

Material and methods: This study is a descriptive and retrospective epidemiologic study that was conducted in 2016 to investigate maternal and fetal complications in SLE patients. We prepared forms of data recording, including age, occupation, and other important information and then analyzed them in SPSS version 22.

Result: The results showed that the presence of anti-phospholipid syndrome in pregnant women can lead to abnormalities such as preterm, IUGR, abortion, and fetal death (P value 0.0001). It also leads to complications such as nephritis, arthritis, and preeclampsia in the mother (P value 0.003). This study suggests that methotrexate and cyclosporine medications could cause fetal developmental disorders. The P value of cyclosporine was 0.0001 and the P value of methotrexate was 0.001.

Conclusion: Anti-phospholipid syndrome in women with SLE who intend to become pregnant can disrupt the development of the embryo. The consumption of methotrexate and cyclosporine medications before and during the pregnancy can have irreparable effects on fetal growth. Key Points • Anti-phospholipid syndrome can disrupt the development of the embryo in women with SLE who intend to become pregnant. • Methotrexate and cyclosporine consumption before and during pregnancy can affect fetal growth. • 7 to 33% of patients whose disease had been suppressed and controlled 6 months before pregnancy seams to relapse during the pregnancy. • Taking medications to control the disease during pregnancy plays an important role in the progression of pregnancy and fetus health.

Keywords: Anti-phospholipid syndrome; Cyclosporine; Fetus complications; Methotrexate; Pregnancy; Systemic lupus erythematous.

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