Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jul 1;168(1):85-94.
doi: 10.1084/jem.168.1.85.

Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells

S Karray  1 , T DeFrance, H Merle-Béral, J Banchereau, P Debré, P Galanaud
Affiliations

Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells

S Karray et al. J Exp Med. .

Abstract

B cells from patients suffering from B-type chronic lymphocytic leukemia (B-CLL) are susceptible to the effects of several interleukins. Using the cells from 12 different patients we show that IL-4 does not synergize with anti-mu antibody for the enhancement of DNA synthesis. Moreover IL-4 profoundly (90%) suppresses the response to IL-2 in the 10 patient responders to this interleukin. This suppression occurs whether IL-2 is used alone, in costimulation with anti-mu antibody, or in synergy with IFN-gamma. In no instance did IL-4 induce terminal differentiation. This negative effect of IL-4 can take place in monoclonal B-CLL cells where IL-4 enhances the expression of CD23. IL-4 does not interfere with the upregulation of CD25 by IL-2. Thus, IL-4 may display inhibitory effects on the proliferative response of selected B cell populations. The antagonism between IL-4 and IL-2 has important implications for the potential use of cytokines in the management of B-CLL patients.

PubMed Disclaimer

References

    1. J Exp Med. 1982 Mar 1;155(3):914-23 - PubMed
    1. J Immunol. 1988 Feb 1;140(3):774-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Oct;81(19):6149-53 - PubMed
    1. J Exp Med. 1985 May 1;161(5):1225-30 - PubMed
    1. J Exp Med. 1985 Nov 1;162(5):1726-31 - PubMed

Publication types