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Review
. 2019 Jul 10:10:713.
doi: 10.3389/fphys.2019.00713. eCollection 2019.

Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

Xuehui Fan  1 , Tianyi Sun  2 , William Crawford  2 , Xiaoqiu Tan  1 , Xianhong Ou  1 , Derek A Terrar  2 , Steven N Ebert  3 , Ming Lei  1   2
Affiliations
Review

Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

Xuehui Fan et al. Front Physiol. .

Abstract

In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca2+ transient properties, and potential role in localized adrenergic signaling are discussed.

Keywords: Pnmt; Pnmt-derived cardiomyocytes; catecholamines; heart; optogenetics.

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Figures

Figure 1
Figure 1
Representative images of the coronal section and selected regions from the section of an adult ChR2/tdTomato mouse heart showing fluorescence and morphology of the ChR2/tdTomato positive cells. (A) A representative coronal section from an adult ChR2/tdTomato mouse heart; (B) inserts of zoom-in views showing tdTomato fluorescence in different regions of the heart; the labeling of the inserts indicates the corresponding locations as marked in (A). SAN, sinoatrial node; AVN, atrioventricular node; LA, left atrium; RA, right atrium; LV, left ventricle; RV, right ventricle; ASEP, atrial septum; VSEP, ventricular septum. (C) Immunostaining of ChR2 with anti-ChR2 antibody; tdTomato fluorescence in isolated LV cardiomyocytes; overlay showing co-localization of ChR2 and tdTomato [Adapted with permission from Wang et al. (2017) and Ni et al. (2017)].
Figure 2
Figure 2
Schematic depiction of how PdCMs are thought to arise in heart development.
See this image and copyright information in PMC

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