Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May 9;29(2):8202.
doi: 10.4081/ejtm.2019.8202. eCollection 2019 May 7.

Relevance of lactate level detection in migrane and fibromyalgia

Patrizia Proia  1 , Alessandra Amato  1 , Valentina Contrò  1 , Alessandra Lo Monaco  1 , Jessica Brusa  1 , Filippo Brighina  2 , Giuseppe Messina  1
Affiliations

Relevance of lactate level detection in migrane and fibromyalgia

Patrizia Proia et al. Eur J Transl Myol. .

Abstract

The aim of this study was to determine the blood lactate levels in healthy and pathological subjects, particularly with migraine and fibromyalgia. Moreover we investigated the possible correlation between lactate concentration, postural stability and balance disorders; the composition of the groups were: migraine (n = 25; age 49.7 ± 12.5), fibromyalgia (n = 10; age 43.7 ± 21.2), control group (n = 16 age 28.52 ± 2.4). The results showed that patients with fibromyalgia (FG) had higher lactate levels compared to migraine (MG) and control group (CG) (mean ± sd: FG = 1.78 ± 0.9 mmol/L; MG = 1.45±1 mmol/L; CG = 0,85 ± 0,07 mmol/L). The same situation was highlighted about the sway path length with eyes closed (FG = 518 ± 195 mm; MG = 465 ± 165 mm; CG = 405 ± 94,72 mm) and with eyes open (FG = 430 ± 220 mm; MG = 411 ± 143 mm; CG = 389 ± 107 mm). This can be explained by the fact that energy-intensive postural strategies must be used to optimize both static and dynamic coordination, in particular with repeated contractions of tonic oxidative muscle cells responsible for postural control.

Keywords: fibromyalgia; lactate level; migraine; postural control.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors declare they have no financial, personal, or other conflicts of interest.We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Figures

Fig 1.
Fig 1.
Correlation between lactate (mmol/L) and sway path length (mm) in FG with open eyes (b) ; Correlation between lactate (mmol/L) and sway path length (mm) in FG with closed eyes(a);Correlation between lactate (mmol/L) and sway path length (mm) in CG with closed eyes (c).
See this image and copyright information in PMC

References

    1. Contrò V, Schiera G, Abbruzzo A, et al. An innovative way to highlight the power of each polymorphism on elite athletes phenotype expression. Eur J Transl Myol 2018;28(1):7186. doi:10.4081/ejtm.2018.7186 - PMC - PubMed
    1. Proia P, Di Liegro CM, Schiera G, et al. Lactate as a Metabolite and a Regulator in the Central Nervous System. Int J Mol Sci 2016;17:1450. - PMC - PubMed
    1. De Sá Ribeiro GA1, Scola RH2, Piovesan EJ3, et al. The importance of lactic acid in migraines and fibromyalgia. Rev Bras Reumatol 2015;55:471-6. - PubMed
    1. Amery WK. Brain hypoxia in migraine: pathophysiologic and therapeutic implications. J Cereb Blood Flow Metab 1982;2(Suppl):S62–5. - PubMed
    1. Amery WK. Brain hypoxia: the turning-point in the genesis of the migraine attack? Cephalalgia 1982;2:83–109. - PubMed