'Big issues' in neurodevelopment for children and adults with congenital heart disease

Charlotte E Verrall^{1

2}, Gillian M Blue^{1

2}, Alison Loughran-Fowlds^{2

3}, Nadine Kasparian^{1

4}, Jozef Gecz⁵, Karen Walker³, Sally L Dunwoodie^{6

7}, Rachael Cordina^{8

9}, Gary Sholler^{1

2}, Nadia Badawi^{2

3}, David Winlaw^{1

2}

Affiliations

¹ Heart Centre for Children, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
² Discipline of Child and Adolescent Health, Sydney Medical School, Faculty of Health and Medicine, University of Sydney, Sydney, NSW, Australia.
³ Grace Centre for Newborn Care, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
⁴ Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia.
⁵ Faculty of Health and Medical Sciences, University of Adelaide School of Medicine, Adelaide, South Australia, Australia.
⁶ Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
⁷ Faculties of Medicine and Science, University of New South Wales, Sydney, NSW, Australia.
⁸ Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
⁹ Discipline of Medicine, Sydney Medical School, Faculty of Health and Medicine, University of Sydney, Sydney, NSW, Australia.

PMID: 31354955
PMCID: PMC6615801
DOI: 10.1136/openhrt-2018-000998

Review

'Big issues' in neurodevelopment for children and adults with congenital heart disease

Charlotte E Verrall et al. Open Heart. 2019.

. 2019 Jul 3;6(2):e000998.

doi: 10.1136/openhrt-2018-000998. eCollection 2019.

Authors

Affiliations

¹ Heart Centre for Children, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
² Discipline of Child and Adolescent Health, Sydney Medical School, Faculty of Health and Medicine, University of Sydney, Sydney, NSW, Australia.
³ Grace Centre for Newborn Care, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
⁴ Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia.
⁵ Faculty of Health and Medical Sciences, University of Adelaide School of Medicine, Adelaide, South Australia, Australia.
⁶ Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
⁷ Faculties of Medicine and Science, University of New South Wales, Sydney, NSW, Australia.
⁸ Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
⁹ Discipline of Medicine, Sydney Medical School, Faculty of Health and Medicine, University of Sydney, Sydney, NSW, Australia.

PMID: 31354955
PMCID: PMC6615801
DOI: 10.1136/openhrt-2018-000998

Abstract

It is established that neurodevelopmental disability (NDD) is common in neonates undergoing complex surgery for congenital heart disease (CHD); however, the trajectory of disability over the lifetime of individuals with CHD is unknown. Several 'big issues' remain undetermined and further research is needed in order to optimise patient care and service delivery, to assess the efficacy of intervention strategies and to promote best outcomes in individuals of all ages with CHD. This review article discusses 'gaps' in our knowledge of NDD in CHD and proposes future directions.

Keywords: congenital heart disease; genetics; paediatric cardiology; quality of care and outcomes.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

**Figure 1**
Potential manifestations of NDD in people with CHD and associated long-term outcomes. ADHD, attention-deficit/hyperactivity disorder; CHD, congenital heart disease; NDD, neurodevelopmental disability.

See this image and copyright information in PMC

References

1. Denniss DL, Sholler GF, Costa DSJ, et al. . Need for Routine Screening of Health-Related Quality of Life in Families of Young Children with Complex Congenital Heart Disease. J Pediatr 2019;205:21-28.e2 10.1016/j.jpeds.2018.09.037 - DOI - PubMed
1. Verrall CE, Walker K, Loughran-Fowlds A, et al. . Contemporary incidence of stroke (focal infarct and/or haemorrhage) determined by neuroimaging and neurodevelopmental disability at 12 months of age in neonates undergoing cardiac surgery utilizing cardiopulmonary bypass†. Interact Cardiovasc Thorac Surg 2018;26:644–50. 10.1093/icvts/ivx375 - DOI - PubMed
1. Walker K, Badawi N, Halliday R, et al. . Early Developmental Outcomes following Major Noncardiac and Cardiac Surgery in Term Infants: A Population-Based Study. J Pediatr 2012;161:748–52. 10.1016/j.jpeds.2012.03.044 - DOI - PubMed
1. Walker K, Loughran-Fowlds A, Halliday R, et al. . Developmental outcomes at 3 years of age following major non-cardiac and cardiac surgery in term infants: A population-based study. J Paediatr Child Health 2015;51:1221–5. 10.1111/jpc.12943 - DOI - PubMed
1. Gaynor JW, Stopp C, Wypij D, et al. . Neurodevelopmental Outcomes After Cardiac Surgery in Infancy. Pediatrics 2015;135:816–25. 10.1542/peds.2014-3825 - DOI - PMC - PubMed

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'Big issues' in neurodevelopment for children and adults with congenital heart disease

Affiliations

'Big issues' in neurodevelopment for children and adults with congenital heart disease

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

LinkOut - more resources

Full Text Sources