doi: 10.1212/wnl.38.8.1319.
Effect of food on the serum concentration profile of enteric-coated valproic acid
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- PMID: 3135514
- DOI: 10.1212/wnl.38.8.1319
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Effect of food on the serum concentration profile of enteric-coated valproic acid
Neurology.
1988 Aug.
Abstract
We evaluated the effect of food on the serum concentration profile of enteric-coated divalproex sodium (EC-VPA) in six adult volunteers following a single dose and in six patients during chronic-dose administration. The results demonstrated a significant delay but no decrease in extent of EC-VPA absorption following administration with food. To monitor serum concentrations in patients receiving EC-VPA, consideration of sampling time in relation both to time of dose and meals is required.
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