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. 1988 Aug;38(8):1319-22.
doi: 10.1212/wnl.38.8.1319.

Effect of food on the serum concentration profile of enteric-coated valproic acid

J H Fischer  1 , A N Barr, F P Paloucek, J V Dorociak, A L Spunt
Affiliations

Effect of food on the serum concentration profile of enteric-coated valproic acid

J H Fischer et al. Neurology. 1988 Aug.

Abstract

We evaluated the effect of food on the serum concentration profile of enteric-coated divalproex sodium (EC-VPA) in six adult volunteers following a single dose and in six patients during chronic-dose administration. The results demonstrated a significant delay but no decrease in extent of EC-VPA absorption following administration with food. To monitor serum concentrations in patients receiving EC-VPA, consideration of sampling time in relation both to time of dose and meals is required.

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