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Review
. 2019 Jul 2:2019:4649705.
doi: 10.1155/2019/4649705. eCollection 2019.

Potential Role of Exosomes in Cancer Metastasis

Wenjuan Tian  1   2 , Shanshan Liu  1   2 , Burong Li  1
Affiliations
Review

Potential Role of Exosomes in Cancer Metastasis

Wenjuan Tian et al. Biomed Res Int. .

Abstract

High cancer mortality is attributed to metastasis to a large extent. However, cancer metastasis remains devoid of dynamic monitoring and early prevention in terms of current advances in diagnostic means and therapeutic modalities. Meanwhile, studies have shown that reciprocal crosstalk among cells via exosomes plays a critical role in maintaining normal physiological state or triggering disease progression, including cancer metastasis. Therefore, in this review, we focus on the latest literature (primarily from 2018) to summarize action mechanisms and experimental studies of exosomes in cancer metastasis and put forward some problems as well as new outlooks of these studies.

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Figures

Figure 1
Figure 1
Role of exosomes in organ-specific targeting. Pancreatic ductal adenocarcinoma, PDAC.
Figure 2
Figure 2
Influence of exosomes in changing the efficacy of chemotherapy. Tumor associated macrophage, TAM; epithelial ovarian cancer, EOC; ↑, upregulated.
See this image and copyright information in PMC

References

    1. American Cancer Society. Global Cancer Facts & Figures. 4th. Atlanta, GA, USA: American Cancer Society; 2018.
    1. Steeg P. S. Targeting metastasis. Nature Reviews Cancer. 2016;16(4):201–218. doi: 10.1038/nrc.2016.25. - DOI - PMC - PubMed
    1. Siegel R. L., Miller K. D., Jemal A. Cancer statistics, 2019. CA: A Cancer Journal for Clinicians. 2019;69(1):7–34. doi: 10.3322/caac.21551. - DOI - PubMed
    1. Anderson R. L., Balasas T., Callaghan J., et al. A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology. 2019;16(3):185–204. doi: 10.1038/s41571-018-0134-8. - DOI - PMC - PubMed
    1. Akhtar M., Haider A., Rashid S., Al-Nabet A. Paget's "Seed and Soil" Theory of Cancer Metastasis: An Idea Whose Time has Come. (1533-4031 (Electronic)) - DOI - PubMed

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