Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2019 Jul 2:2019:6392751.
doi: 10.1155/2019/6392751. eCollection 2019.

Association between Blood Potassium Level and Recovery of Postoperative Gastrointestinal Motility during Continuous Renal Replacement Therapy in Patient Undergoing Open Abdominal Surgery

Yi Yang  1 , Jingjuan Yang  1   2 , Xiner Yao  1   3 , Yu Cui  1 , Xiabing Lang  1 , Binbin Wu  1 , Ping Zhang  1 , Jianghua Chen  1
Affiliations
Clinical Trial

Association between Blood Potassium Level and Recovery of Postoperative Gastrointestinal Motility during Continuous Renal Replacement Therapy in Patient Undergoing Open Abdominal Surgery

Yi Yang et al. Biomed Res Int. .

Abstract

Background: The aim of this study was to identify the blood potassium level beneficial to the postoperative recovery of gastrointestinal motility during continuous renal replacement therapy (CRRT) in patient undergoing open abdominal surgery.

Materials and methods: 538 critically ill patients after open abdominal surgery and receiving CRRT were retrospectively recruited as the study cohort. Demographic and clinical data were recorded along with an evaluation of the postoperative gastrointestinal motility.

Results: Correlation analysis was used to assess the correlation coefficient, and then the variables with correlation coefficient value less than 0.5 were included in the binary logistic regression model. Binary logistic regression model indicated that the postoperative blood potassium level was independently associated with the recovery of gastrointestinal motility (OR=0.109, 95% CI= 0.063 to 0.190, p<0.001). Based on the normal range of blood potassium level, we selected the cut-off point of blood potassium level via Weight of Evidence analysis, which was 4.00 mmol/L. Compared with the patients with insufficient blood potassium levels (plasma potassium concentration < 4.00 mmol/L), those with sufficient blood potassium levels (plasma potassium concentration≥ 4.00 mmol/L) conferred an increase in the rate of 4-day postoperative recovery of gastrointestinal motility (OR= 4.425, 95% CI = 2.933 to 6.667, p<0.001).

Conclusions: Maintaining the blood potassium concentrations at a relatively high level of the normal blood potassium range during CRRT would be beneficial to postoperative recovery of gastrointestinal motility.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Correlation analysis between variables. It demonstrated that correlation coefficient between length of ICU stay and initial time of CRRT after operation was 0.62 and between delivered dose of CRRT and prescribed dose of CRRT was 0.58. A correlation coefficient value greater than 0.5 was considered to be relevant.
Figure 2
Figure 2
Kaplan–Meier analysis between blood potassium level and postoperative gastrointestinal motility. It indicated that, compared with the patients with insufficient blood potassium levels (plasma potassium concentration < 4.00 mmol/L), those with sufficient levels (plasma potassium concentration ≥4.00 mmol/L) had higher rates of 4-day postoperative recovery of gastrointestinal motility (p<0.001).
Figure 3
Figure 3
Correlation analysis between variables. Among them, blood potassium concentration was defined as insufficient group and sufficient group. It demonstrated that correlation coefficient between length of ICU stay and initial time of CRRT after operation was 0.62 and between delivered dose of CRRT and prescribed dose of CRRT was 0.58. A correlation coefficient value greater than 0.5 was considered to be relevant.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Collins T. C., Daley J., Henderson W. H., Khuri S. F. Risk factors for prolonged length of stay after major elective surgery. Annals of Surgery. 1999;230(2):251–259. doi: 10.1097/00000658-199908000-00016. - DOI - PMC - PubMed
    1. Geltzeiler C. B., Rotramel A., Wilson C., Deng L., Whiteford M. H., Frankhouse J. Prospective study of colorectal enhanced recovery after surgery in a community hospital. JAMA Surgery. 2014;149(9):955–961. doi: 10.1001/jamasurg.2014.675. - DOI - PubMed
    1. Johnson M. D., Walsh R. M. Current therapies to shorten postoperative ileus. Cleveland Clinic Journal of Medicine. 2009;76(11):641–648. doi: 10.3949/ccjm.76a.09051. - DOI - PubMed
    1. Lobo D. N., Bostock K. A., Neal K. R., Perkins A. C., Rowlands B. J., Allison S. P. Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial. The Lancet. 2002;359(9320):1812–1818. doi: 10.1016/S0140-6736(02)08711-1. - DOI - PubMed
    1. González-Fajardo J., Mengibar L., Brizuela J., Castrodeza J., Vaquero-Puerta C. Effect of postoperative restrictive fluid therapy in the recovery of patients with abdominal vascular surgery. European Journal of Vascular and Endovascular Surgery. 2009;37(5):538–543. doi: 10.1016/j.ejvs.2009.01.010. - DOI - PubMed

Publication types