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. 2019 Sep 30;38(3):365-372.
doi: 10.23876/j.krcp.18.0155.

Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease

Luis D'Marco  1   2 , Juan Salazar  3 , Marie Cortez  2 , María Salazar  2 , Marjorie Wettel  2 , Marcos Lima-Martínez  4 , Edward Rojas  5 , Willy Roque  5 , Valmore Bermúdez  3
Affiliations

Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease

Luis D'Marco et al. Kidney Res Clin Pract. .

Abstract

Background: Adipose tissue accumulation in specific body compartments has been associated with diabetes, hypertension and dyslipidemia. Perirenal fat (PRF) may lead to have direct lipotoxic effects on renal function and intrarenal hydrostatic pressure. This study was undertaken to explore the association of PRF with cardiovascular risk factors and different stages of chronic kidney disease (CKD).

Methods: We studied 103 patients with CKD of different stages (1 to 5). PRF was measured by B-mode renal ultrasonography in the distal third between the cortex and the hepatic border and/or spleen.

Results: The PRF thickness was greater in CKD patients with impaired fasting glucose than in those with normal glucose levels (1.10 ± 0.40 cm vs. 0.85 ± 0.39 cm, P < 0.01). Patients in CKD stages 4 and 5 (glomerular filtration rate [GFR] < 30 mL/min/1.73 m2) had the highest PRF thickness. Serum triglyceride levels correlated positively with the PRF thickness; the PRF thickness was greater in patients with triglyceride levels ≥ 150 mg/dL (1.09 ± 0.40 cm vs. 0.86 ± 0.36 cm, P < 0.01). In patients with a GFR < 60 mL/min/1.73 m2, uric acid levels correlated positively with the PRF thickness (P < 0.05).

Conclusion: In CKD patients, the PRF thickness correlated significantly with metabolic risk factors that could affect kidney function.

Keywords: Cardiovascular; Chronic kidney disease; Diabetes; Metabolic risk; Perirenal fat; Renal insufficiency.

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Conflict of interest statement

Conflicts of interest

All authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1. Perirenal fat thickness measurement.
Perirenal fat was measured in the distal third between the cortex and the hepatic border and/or spleen.
Figure 2
Figure 2. Distribution of diabetes mellitus patients according to the estimated glomerular filtration rate.
Figure 3
Figure 3. Distribution of patients according to tertile of perirenal fat and uric acid levels.
See this image and copyright information in PMC

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