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. 2019 Sep 23;63(10):e01273-19.
doi: 10.1128/AAC.01273-19. Print 2019 Oct.

Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia

Rithea Leang  1 , Nimol Khim  2 , Huch Chea  3 , Rekol Huy  3 , Melissa Mairet-Khedim  2 , Denis Mey Bouth  4 , Maria Dorina Bustos  5 , Pascal Ringwald  6 , Benoit Witkowski  2
Affiliations

Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia

Rithea Leang et al. Antimicrob Agents Chemother. .

Abstract

This single-arm trial (n = 104) in western Cambodia showed high efficacy for 3-day treatment with pyronaridine-artesunate plus single-dose primaquine in Plasmodium falciparum malaria. Day 42 PCR-adjusted adequate clinical and parasitological response (ACPR) was 98.3% (58/59) (95% confidence interval [CI], 90.9 to 100.0) in Trapeng Chau in Kampong Speu and 100% (41/41) (95% CI, 91.4 to 100) in Veal Veng in Pursat; 80.6% (83/103) of the patients had P. falciparum with drug resistance molecular markers. For Plasmodium vivax malaria, pyronaridine-artesunate day 28 ACPR was 98.3% (59/60) (95% CI, 91.1 to 100) and 100% (60/60) (95% CI, 94.0 to 100), respectively. (This study is registered in the Australian New Zealand Clinical Trials Registry [ANZCTR] under reference no. ACTRN12618001999224.).

Keywords: Cambodia; Plasmodium falciparum; Plasmodium vivax; antimalarial agents; artemisinin; drug resistance; malaria; pyronaridine-artesunate.

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Figures

FIG 1
FIG 1
Prevalence of molecular markers associated with resistance to artemisinin (K13), piperaquine (Pfpm2), and mefloquine (Pfmdr1). Note that data were incomplete for one patient from Trapeng Chau.
See this image and copyright information in PMC

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