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. 1988 Jun 18;296(6638):1726-7.
doi: 10.1136/bmj.296.6638.1726.

Causes of venous ulceration: a new hypothesis

P D Coleridge Smith  1 , P Thomas, J H Scurr, J A Dormandy
Affiliations

Causes of venous ulceration: a new hypothesis

P D Coleridge Smith et al. Br Med J (Clin Res Ed). .

Abstract

Previous hypotheses about the causes of venous ulceration are inconsistent with recently published data. In patients with chronic venous insufficiency the number of functioning capillary loops visible in the skin on microscopy fell after the legs had been dependent for 30 minutes. Another study had shown that leucocytes became trapped in the circulation in dependent legs. A new hypothesis linking these two findings proposes that the trapped white cells occlude the capillaries and result in ischaemia of the skin of the leg.

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