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. 2019 Dec:94 Suppl 2:4-10.
doi: 10.1111/tan.13645.

Combined association of recipient killer cell immunoglobulin-like haplotype AA and donor HLA-C*07 gene with BK virus associated nephropathy in kidney transplant patients

Ivana Kovacevic Vojtusek  1 , Marija Burek Kamenaric  2 , Vanja Ivkovic  1 , Stela Bulimbasic  3 , Ivana Marekovic  4 , Marijana Coric  3 , Zrinka Bosnjak  4 , Zorana Grubic  2 , Renata Zunec  2
Affiliations

Combined association of recipient killer cell immunoglobulin-like haplotype AA and donor HLA-C*07 gene with BK virus associated nephropathy in kidney transplant patients

Ivana Kovacevic Vojtusek et al. HLA. 2019 Dec.

Abstract

Kidney transplant recipient killer cell immunoglobulin-like receptors (KIR) genotype and HLA-C status of their donors have been separately associated with BK virus-associated nephropathy (BKVAN) and BK virus infection. Our aim was to determine whether different combinations of recipients KIR genes and donor HLA-C ligands influence the risk of BKVAN. Retrospective case-control study included 23 recipients with BKVAN and 46 recipients with persistently negative BK virus. Donor HLA-C*07 positivity was associated with lower odds for BKVAN, recipients bearing KIR haplotype AA or lacking any activating KIR genes were more frequent in BKVAN while recipient/donor combination HLA-C*07 negative/KIR AA positive was significantly associated with BKVAN. Our study complements and confirms results from several previously published studies, suggesting potential clinical usefulness.

Keywords: BK virus; KIR genes; kidney transplantation.

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References

REFERENCES

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