Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1988 Jun;20(3):365-82.
doi: 10.1007/BF00769638.

Molecular defects of NADH-ubiquinone oxidoreductase (complex I) in mitochondrial diseases

J A Morgan-Hughes  1 , A H Schapira, J M Cooper, J B Clark
Affiliations
Review

Molecular defects of NADH-ubiquinone oxidoreductase (complex I) in mitochondrial diseases

J A Morgan-Hughes et al. J Bioenerg Biomembr. 1988 Jun.

Abstract

Defects in Complex I of the mitochondrial respiratory chain have been identified in 38 patients. The clinical and laboratory features are reviewed and the results of recently devised strategies aimed at characterizing the primary molecular and genetic abnormalities are presented. Although not exhaustive, these studies have provided a molecular basis for the contention that defects in Complex I may have their origin in nuclear or in mitochondrial genes.

PubMed Disclaimer

References

    1. Biochemistry. 1982 May 11;21(10):2518-24 - PubMed
    1. Eur J Biochem. 1983 Jul 15;134(1):145-50 - PubMed
    1. Nature. 1981 Apr 9;290(5806):457-65 - PubMed
    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Biochem Soc Trans. 1987 Feb;15(1):95-7 - PubMed

Publication types

Substances