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. 2019 Nov 22;60(6):803-811.
doi: 10.1093/jrr/rrz053.

Prognostic value of the expression of epithelial cell adhesion molecules in head and neck squamous cell carcinoma treated by definitive radiotherapy

Naoya Murakami  1 , Taisuke Mori  2 , Satoshi Nakamura  1 , Seiichi Yoshimoto  3 , Yoshitaka Honma  4 , Takao Ueno  5 , Kenya Kobayashi  3 , Tairo Kashihara  1 , Kana Takahashi  1 , Koji Inaba  1 , Kae Okuma  1 , Hiroshi Igaki  1 , Yuko Nakayama  1 , Jun Itami  1
Affiliations

Prognostic value of the expression of epithelial cell adhesion molecules in head and neck squamous cell carcinoma treated by definitive radiotherapy

Naoya Murakami et al. J Radiat Res. .

Abstract

A reliable biomarker can contribute to appropriate treatment selection in the management of head and neck squamous cell carcinoma (HNSCC). Recently, epithelial cell adhesion molecule (EpCAM) was shown to have prognostic features in several malignancies. However, it remains to be elucidated whether EpCAM predicts prognosis of HNSCC after radiotherapy. Therefore, the prognostic potential of EpCAM in HNSCC patients treated by radiotherapy was investigated in this study. All HNSCCs patients examined between January 2013 and December 2015 were analyzed for the expression of EpCAM. One hundred HNSCC patients were identified who were treated by primary radiotherapy. Intense expression of EpCAM was found in 29 HNSCC patients. Two-year overall survival (OS) for patients with intense EpCAM expression was 62.2%, whereas it was 87.9% for those without (P = 0.011). In multivariate analysis, intense EpCAM expression was found to be an independent prognostic factors for OS (P = 0.036). Overall, EpCAM was found to be an independent prognostic factor for HNSCC.

Keywords: BerEP4; EpCAM; biomarker; head and neck squamous cell carcinoma; primary radiation therapy.

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Figures

Fig. 1.
Fig. 1.
Typical staining patterns of BerEP4 are shown. The positivity of BerEP4 was defined as follows: (−) negative, (+) weak to moderate expression, and (++) intense expression.
Fig. 2.
Fig. 2.
Consolidated Standards of Reporting Trials (CONSORT) flow diagram of consecutive HNSCC patients whose biopsy specimens were handed to our Department of Pathology from January 2013 to December 2015.
See this image and copyright information in PMC

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