Functionalized theranostic nanocarriers with bio-inspired polydopamine for tumor imaging and chemo-photothermal therapy

Abstract

Nanocarriers sensitive to near infrared light (NIR) are useful templates for chemo-photothermal therapy (PTT) and imaging of tumors due to the ability to change the absorbed NIR energy to heat. The conventional photo-absorbing reagents lack the efficient loading and release of drug before reaching the target site leading to insufficient therapeutic outcomes. To overcome these limitations, the surface of nanocarriers can be modified with different polymers with wide functionalities to provide systems with diagnostic, therapeutic, and theranostic capabilities. Among various polymers, polydopamine (PDA) has been more interested due to complex structure with various chemical moieties, and the capacity to be used through different coating mechanism. In this review, we describe the complex structure, chemical properties, and coating mechanisms of PDA. Moreover, the advantage and surface modification of some relevant nanosystems based on carbon materials, gold, iron oxide, manganese, and upconverting nanomaterials by using PDA will be discussed, in detail.

Keywords: Cancer; Imaging; Nanocarriers; Photothermal therapy; Polydopamine; Surface modification.