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Review
. 2020 Mar;18(3):534-542.
doi: 10.1016/j.cgh.2019.07.045. Epub 2019 Jul 27.

Burden of Gastric Cancer

Aaron P Thrift  1 , Hashem B El-Serag  2
Affiliations
Review

Burden of Gastric Cancer

Aaron P Thrift et al. Clin Gastroenterol Hepatol. 2020 Mar.

Abstract

Gastric cancer is a global health problem, with more than 1 million people newly diagnosed with gastric cancer worldwide each year. Despite its worldwide decline in incidence and mortality over the past 5 decades, gastric cancer remains the third leading cause of cancer-related death. Knowledge of global as well as regional epidemiology and risk factors for gastric cancer is essential for the practicing gastroenterologist to make personalized decisions about risk stratification, screening, and prevention. In this article, we review the epidemiology of gastric cancer as well as screening and prevention efforts to reduce global morbidity and mortality from gastric cancer. First, we discuss the descriptive epidemiology of gastric cancer, including its incidence, mortality, survival, and secular trends. We combine a synthesis of published studies with an analysis of data from the International Agency for Research on Cancer GLOBOCAN project to describe the global burden of gastric cancer and data from the US Cancer Statistics registry to discuss the change in incidence of gastric cancer in the United States. Next, we summarize current knowledge of risk factors for gastric cancer. Finally, we discuss prevention strategies and screening efforts for gastric cancer.

Keywords: Epidemiology; Gastric Cancer; Helicobacter pylori; Risk Factors; Screening; Surveillance.

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Conflict of interest statement

Conflicts of Interest: The authors disclose no conflicts.

Figures

Figure 1.
Figure 1.
Trends in incidence rates of gastric cancer among (A) men and (B) women in select countries in the International Agency for Research on Cancer (IARC) GLOBOCAN project
Figure 1.
Figure 1.
Trends in incidence rates of gastric cancer among (A) men and (B) women in select countries in the International Agency for Research on Cancer (IARC) GLOBOCAN project
Figure 2.
Figure 2.
Stage distribution of incident cases of gastric cancer in the United States Cancer Statistics registry, 2001–2015
Figure 3.
Figure 3.
Five-year survival rates for gastric cancer in the Surveillance, Epidemiology, and End Results (SEER) 18 program, 2000–2010
Figure 4.
Figure 4.
Age-adjusted gastric cancer incidence rates between 2001 and 2015 by (A) sex and (B) race/ethnicity
Figure 4.
Figure 4.
Age-adjusted gastric cancer incidence rates between 2001 and 2015 by (A) sex and (B) race/ethnicity
Figure 5.
Figure 5.
Heat maps showing age-adjusted gastric cancer incidence rates in the United States in 2003, 2010, and 2015
See this image and copyright information in PMC

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