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. 2019 Mar;58(1):42-49.
doi: 10.20471/acc.2019.58.01.06.

CORRELATION OF PERITUMORAL BRAIN EDEMA WITH MORPHOLOGICAL CHARACTERISTICS AND KI67 PROLIFERATIVE INDEX IN RESECTED INTRACRANIAL MENINGIOMAS

Hakija Bečulić  1 , Rasim Skomorac  1 , Aldin Jusić  1 , Fahrudin Alić  1 , Anes Mašović  1 , Eldin Burazerović  1 , Ibrahim Omerhodžić  1 , Mirsad Dorić  1 , Melica Imamović  1 , Alma Mekić-Abazović  1 , Alma Efendić  1 , Dalma Udovčić-Gagula  1
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CORRELATION OF PERITUMORAL BRAIN EDEMA WITH MORPHOLOGICAL CHARACTERISTICS AND KI67 PROLIFERATIVE INDEX IN RESECTED INTRACRANIAL MENINGIOMAS

Hakija Bečulić et al. Acta Clin Croat. 2019 Mar.

Abstract

The aim of the study was to analyze correlation between morphological characteristics of intracranial meningiomas and Ki67 labeling index (Ki67 LI), and their influence on peritumoral brain edema (PTBE). There were 41 consecutive patients with intracranial meningiomas surgically treated at the Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina, during the period from January 2010 to December 2015. We reviewed clinical data including patient age, gender, magnetic resonance imaging (MRI) characteristics of the tumor and peritumoral edema, tumor margins, intraoperative characteristics, histopathologic grade and Ki67 LI. In all cases, follow up MRI was obtained at about three months after resection and PTBE was analyzed. Our research showed the tumor volume, tumor margins, and intraoperative signs of arachnoidal and pial invasion to be associated with PTBE in intracranial meningiomas. Ki67 LI expression correlated with PTBE. This study showed the resolution of PTBE to depend on invasive behavior of meningioma and KI67 LI. PTBE, pial/cortical and arachnoidal invasion significantly influence the extent of surgical resection.

Keywords: Brain edema; Cell proliferation; Ki-67 antigen; Meningeal neoplasms; Meningioma.

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Figures

Fig. 1
Fig. 1
Correlation of tumor margins and Ki67 LI.
Fig. 2
Fig. 2
Pial, dural and sinus invasion and bone infiltration.
Fig. 3
Fig. 3
Correlation of Ki67 LI with pial, dural and sinus invasion, and bone infiltration.
See this image and copyright information in PMC

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