Management of muscular dystrophy during osteoarthritis disorder: A topical phytotherapeutic treatment protocol

Abstract

Background: Creatine kinase-muscle (CK-MM) and aldolase A (AldoA) levels are proven to be realistic biochemical markers to detect muscular dystrophy during osteoarthritic disorders (MD-OADs). The aim of this study is to normalize the MD-OADs characterized by muscle weakness, atrophy, inflammatory disorders, pain with chronic arthropathy by specialized topical phytotherapeutic treatment.

Methods: Baseline data were collected and evaluated from 153 patients, aged 59.89±11.37years, and suffering with MD-OADs for 7.89±1.90 years. Serum CK-MM and aldoA levels were measured at baseline and after a six- week treatment using the appropriate kits. All patients underwent standardized physical, radiographic examinations and completed a questionnaire. All the patients were treated with topical application of phytoconstituents from the extracts of seven Indian medicinal plants namely Cissus quadrangularis, Calotropis gigantea, Zingiber officinalis, Rosemarinus officinale, Boswellia serratia, Curcuma longa and Withata somnifera mixed with sesame oil and beehives wax for six-week.

Results: The elevated levels of biomarkers, CK-MM and aldoA, were reduced to their mean±SEM values 82.77±1.32 and 4.94±1.30U/L, respectively at the end of six-week treatment and the improvements of deranged anatomical features, Pearson's correlation coefficients, international-approved pain related abnormalities (VAS, WOMAC, KPS and KOOS) and reduction of weight at the end of treatment were all highly significant (p<0.0001).

Conclusion: It is firmly confirmed that MD-OADs resulted with the elevated levels of CK-MM, and AldoA, along with deranged anatomical features (KGB, DTM, DCM, DAP, DBP, SLR, KFS and KES) and pain related parameters (VAS, WOMAC-index, KPS, KOOS and BMI) can be successfully normalized by topical phytotherapeutic treatment protocol.

Keywords: Muscular dystrophy; Normalized serum markers; OAD with muscular dystrophy.; Phytotherapy; Specific biomarkers.

Figure 1

Percentage of improvement of biomarkers CK-MM and aldoA and their ratios at the end of the 6-week treatment (*p<0.0001)

Figure 2

percentage of Improvement of pain under VAS after 6-week treatment (*p<0.0001)

Figure 3

% of Improvement of pain, stiffness & physical function under WOMAC index after the 6-week treatment (*p<0.0001)

Figure 4

% of Improvement of pain under KPS after 6-week treatment (*p<0.0001)

Figure 5

% of Improvement on reduction of body weight as assessed by BMI after 6-week treatment (*p<0.0001)

Figure 6

KOOS Profiles before and after the treatment of six weeks by phytotherapy. Mean KOOS score (n=153) at the baseline and at the end of six weeks assessment (*p<0.0001)

Figure 7

AP views of x-ray for knee-joint and lumbar vertebrae before and after the treatment