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. 2019 Jul 1;6(7):ofz288.
doi: 10.1093/ofid/ofz288.

The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions

Michael H Woodworth  1 , Mary K Hayden  2 , Vincent B Young  3 , Jennie H Kwon  4
Affiliations

The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions

Michael H Woodworth et al. Open Forum Infect Dis. .

Erratum in

Abstract

The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and a potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established as an effective treatment for recurrent Clostridioides difficile infection and may be an effective approach for reducing intestinal ARO colonization. In this article, we review the current published literature on the role of FMT for eradication of intestinal ARO colonization, review the potential benefit and limitations of the use of FMT in this setting, and outline a research agenda for the future study of FMT for intestinal ARO colonization.

Keywords: antibiotic resistance; antibiotic-resistant organism; fecal microbiota transplantation; hospital epidemiology; microbiome; multidrug-resistant organisms; resistome.

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Figures

Figure 1.
Figure 1.
Concept illustration of intestinal microbial diversity as a protective factor against colonization with antibiotic-resistant organisms (AROs), adapted from Halpin et al [25]. Antibiotic exposure can lead to disruption of these community structures and subsequent colonization and dominance by AROs, which may increase risk of infection and transmission to other patients. Fecal microbiota transplantation may reduce risk of ARO colonization and transmission by increasing intestinal microbiome diversity.
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