Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
- PMID: 3136397
- DOI: 10.1038/334535a0
Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
Abstract
Before quiescent cells can respond to mitogens and progress through the G1 phase of cell growth, new messenger RNA synthesis is required. The G1 phase seems to be a critical point of control in the cell cycle, where normal cells deprived of growth factors halt cycling while transformed cells do not, suggesting that regulatory genes, uncontrolled in the neoplastic phenotype, are expressed during the G0 to G1 transition. Some of these may code for nuclear proteins that participate in the transactivation of genes required for the progression through G1. The observed changes in expression of the proto-oncogenes c-fos and c-myc, following stimulation of fibroblasts with growth factors, support this notion as recent evidence suggests that c-FOS and c-MYC proteins can function as transactivating factors. Moreover, the rapid induction of several genes in fibroblasts coding for putative transacting factors during the G0 to G1 transition has been recently reported. Here we present the nucleotide sequence of a mouse cDNA clone coding for a 334 residue protein which shows 80% similarity with v-JUN and more than 98% similarity with the human c-JUN sequence. We have demonstrated that in quiescent fibroblasts c-jun transcription is rapidly induced during the G0 to G1 transition.
Similar articles
-
Differential regulation and expression of jun, c-fos and c-myc proto-oncogenes during mouse liver regeneration and after inhibition of protein synthesis.Oncogene. 1990 Oct;5(10):1511-9. Oncogene. 1990. PMID: 2123531
-
Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts.Nature. 1988 Aug 11;334(6182):538-9. doi: 10.1038/334538a0. Nature. 1988. PMID: 3136398
-
Induction of proto-oncogene JUN/AP-1 by serum and TPA.Nature. 1988 Aug 18;334(6183):629-31. doi: 10.1038/334629a0. Nature. 1988. PMID: 2457172
-
Regulation of cell cycle entry and G1 progression by CSF-1.Mol Reprod Dev. 1997 Jan;46(1):11-8. doi: 10.1002/(SICI)1098-2795(199701)46:1<11::AID-MRD3>3.0.CO;2-U. Mol Reprod Dev. 1997. PMID: 8981358 Review.
-
Genes induced during the G0/G1 transition in mouse fibroblasts.Semin Cancer Biol. 1990 Feb;1(1):37-46. Semin Cancer Biol. 1990. PMID: 2133109 Review.
Cited by
-
Trans-dominant negative mutants of Fos and Jun.Proc Natl Acad Sci U S A. 1990 May;87(10):3806-10. doi: 10.1073/pnas.87.10.3806. Proc Natl Acad Sci U S A. 1990. PMID: 2111017 Free PMC article.
-
Cell cycle and gene expression in the insulin producing pancreatic cell line beta TC1.Diabetologia. 1990 Oct;33(10):586-92. doi: 10.1007/BF00400201. Diabetologia. 1990. PMID: 1701744
-
Overexpression of c-jun, junB, or junD affects cell growth differently.Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8890-4. doi: 10.1073/pnas.88.20.8890. Proc Natl Acad Sci U S A. 1991. PMID: 1924349 Free PMC article.
-
Characterization of junD: a new member of the jun proto-oncogene family.EMBO J. 1989 May;8(5):1433-9. doi: 10.1002/j.1460-2075.1989.tb03525.x. EMBO J. 1989. PMID: 2504580 Free PMC article.
-
DNA binding site of the growth factor-inducible protein Zif268.Proc Natl Acad Sci U S A. 1989 Nov;86(22):8737-41. doi: 10.1073/pnas.86.22.8737. Proc Natl Acad Sci U S A. 1989. PMID: 2510170 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous