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. 2019 Jul;23(14):6234-6241.
doi: 10.26355/eurrev_201907_18442.

Long noncoding RNA NEAT1 functions as an oncogene in human laryngocarcinoma by targeting miR-29a-3p

T Liu  1 , W Wang, Y-C Xu, Z-W Li, J Zhou
Affiliations
Free article

Long noncoding RNA NEAT1 functions as an oncogene in human laryngocarcinoma by targeting miR-29a-3p

T Liu et al. Eur Rev Med Pharmacol Sci. 2019 Jul.
Free article

Expression of concern in

  • Expression of Concern.
    Authors Listed N. Authors Listed N. Eur Rev Med Pharmacol Sci. 2025 Jun;29(6):287-288. doi: 10.26355/eurrev_202506_37270. Eur Rev Med Pharmacol Sci. 2025. PMID: 40613620

Abstract

Objective: Long noncoding RNAs (lncRNAs) have been reported to participate in the progression and development of many human diseases. In this study, we are committed to uncover the potential function of lncRNA Nuclear Enriched Abundant Transcript 1 (NEAT1) in the development of laryngocarcinoma.

Patients and methods: LncRNA NEAT1 expression in laryngocarcinoma cells and 54 paired laryngocarcinoma samples was detected by Real-time quantitative polymerase chain reaction (RT-qPCR). Furthermore, the regulatory effects of NEAT1 on the proliferation and metastasis of laryngocarcinoma cells were evaluated. Biological role of NEAT1/miR-29a-3p axis was finally explored in regulating the progression of laryngocarcinoma.

Results: NEAT1 was upregulated in laryngocarcinoma tissues and cell lines. NEAT1 knockdown suppressed growth and invasive abilities in laryngocarcinoma cells, while overexpression of NEAT1 enhanced such abilities. Further experiments showed that miR-29a-3p was directly targeted by NEAT1, and participated in NEAT-mediated progression of laryngocarcinoma.

Conclusions: NEAT1 is a novel oncogene in laryngocarcinoma and could enhance growth and invasion of laryngocarcinoma cells by targeting miR-29a-3p.

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