Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Sep;7(9):e891.
doi: 10.1002/mgg3.891. Epub 2019 Jul 30.

Genetics of recurrent pregnancy loss among Iranian population

Meysam Moghbeli  1
Affiliations
Review

Genetics of recurrent pregnancy loss among Iranian population

Meysam Moghbeli. Mol Genet Genomic Med. 2019 Sep.

Abstract

Background: Recurrent pregnancy loss (RPL) is one of the most common reproductive disorders which is defined as the occurrence of recurrent miscarriage before 24 weeks of gestation and is observed among 1%-5% of women.

Methods: Various factors are associated with RPL such as immunological disorders, maternal age, obesity, alcohol, chromosomal abnormality, endocrine disorders, and uterine abnormalities. About half of the RPL cases are related with chromosomal abnormalities. Therefore, RPL genetic tests are mainly limited to karyotyping. However, there is a significant proportion of RPL cases without any chromosomal abnormalities that can be related to the single-gene aberrations. Therefore, it is required to prepare a diagnostic panel of genetic markers besides karyotyping.

Results: In the present review, we have summarized all the significant reported genes until now which are associated with RPL among Iranian women. We categorized all the reported genes based on their cellular and molecular functions in order to determine the molecular bases of RPL in this population.

Conclusion: This review paves the way of introducing a population-based diagnostic panel of genetic markers for the first time among Iranian RPL cases. Moreover, this review clarifies the genetic and molecular bases of RPL in this population.

Keywords: Iran; abortion; genetic; marker; miscarriage; recurrent pregnancy loss.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Cellular and molecular processes which are involved in recurrent pregnancy loss among Iranian population
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Aarabi, M. , Memariani, T. , Arefi, S. , Aarabi, M. , Hantoosh Zadeh, S. , Akhondi, M. A. , & Modarressi, M. H. (2011). Polymorphisms of plasminogen activator inhibitor‐1, angiotensin converting enzyme and coagulation factor XIII genes in patients with recurrent spontaneous abortion. The Journal of Maternal‐Fetal & Neonatal Medicine, 24(3), 545–548. 10.3109/14767058.2010.511331 - DOI - PubMed
    1. Abdi‐Shayan, S. , Monfaredan, A. , Moradi, Z. , Rajaii Oskoui, M. , & Kazemi, T. (2016). Association of CD46 IVS1‐1724 C>G single nucleotide polymorphism in Iranian women with unexplained recurrent spontaneous abortion (URSA). Iranian Journal of Allergy, Asthma, and Immunology, 15(4), 303–308. - PubMed
    1. Abediankenari, S. , Farzad, F. , Rahmani, Z. , & Hashemi‐Soteh, M. B. (2015). HLA‐G5 and G7 isoforms in pregnant women. Iranian Journal of Allergy, Asthma, and Immunology, 14(2), 217–221. - PubMed
    1. Aboutorabi, R. , Behzadi, E. , Sadegh, M. J. , Fatehi, S. P. , Semsarzadeh, S. , Zarrin, Y. , … Mostafavi, F. S. (2018). The study of association between polymorphism of TNF‐alpha gene's promoter region and recurrent pregnancy loss. Journal of Reproduction and Infertility, 19(4), 211–218. - PMC - PubMed
    1. Ai, X. , Do, A. T. , Kusche‐Gullberg, M. , Lindahl, U. , Lu, K. , & Emerson, C. P. Jr. (2006). Substrate specificity and domain functions of extracellular heparan sulfate 6‐O‐endosulfatases, QSulf1 and QSulf2. Journal of Biological Chemistry, 281(8), 4969–4976. 10.1074/jbc.M511902200 - DOI - PubMed

LinkOut - more resources