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Review
. 2019 Sep;7(9):e891.
doi: 10.1002/mgg3.891. Epub 2019 Jul 30.

Genetics of recurrent pregnancy loss among Iranian population

Meysam Moghbeli  1
Affiliations
Review

Genetics of recurrent pregnancy loss among Iranian population

Meysam Moghbeli. Mol Genet Genomic Med. 2019 Sep.

Abstract

Background: Recurrent pregnancy loss (RPL) is one of the most common reproductive disorders which is defined as the occurrence of recurrent miscarriage before 24 weeks of gestation and is observed among 1%-5% of women.

Methods: Various factors are associated with RPL such as immunological disorders, maternal age, obesity, alcohol, chromosomal abnormality, endocrine disorders, and uterine abnormalities. About half of the RPL cases are related with chromosomal abnormalities. Therefore, RPL genetic tests are mainly limited to karyotyping. However, there is a significant proportion of RPL cases without any chromosomal abnormalities that can be related to the single-gene aberrations. Therefore, it is required to prepare a diagnostic panel of genetic markers besides karyotyping.

Results: In the present review, we have summarized all the significant reported genes until now which are associated with RPL among Iranian women. We categorized all the reported genes based on their cellular and molecular functions in order to determine the molecular bases of RPL in this population.

Conclusion: This review paves the way of introducing a population-based diagnostic panel of genetic markers for the first time among Iranian RPL cases. Moreover, this review clarifies the genetic and molecular bases of RPL in this population.

Keywords: Iran; abortion; genetic; marker; miscarriage; recurrent pregnancy loss.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Cellular and molecular processes which are involved in recurrent pregnancy loss among Iranian population
See this image and copyright information in PMC

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