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Comment
. 2019 Jul 30;28(5):1117-1118.
doi: 10.1016/j.celrep.2019.07.051.

The Hippocampus Is the Place to Be: Opioid Receptors and LTP

Thomas M Sanderson  1 , John Georgiou  2 , Patrick Tidball  2 , Graham L Collingridge  3
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The Hippocampus Is the Place to Be: Opioid Receptors and LTP

Thomas M Sanderson et al. Cell Rep. .
Free article

Abstract

Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference. These receptors trigger a mechanism involving metabotropic glutamate receptors to enhance hippocampal long-term potentiation, linking the conditioning to the location.

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