Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb;228(2):e13356.
doi: 10.1111/apha.13356. Epub 2019 Aug 19.

Roles of lncRNAs and circRNAs in regulating skeletal muscle development

Rui Chen  1 , Si Lei  1 , Ting Jiang  2 , Jie Zeng  3 , Shanyao Zhou  1 , Yanling She  1
Affiliations
Review

Roles of lncRNAs and circRNAs in regulating skeletal muscle development

Rui Chen et al. Acta Physiol (Oxf). 2020 Feb.

Abstract

The multistep biological process of myogenesis is regulated by a variety of myoblast regulators, such as myogenic differentiation antigen, myogenin, myogenic regulatory factor, myocyte enhancer factor2A-D and myosin heavy chain. Proliferation and differentiation during skeletal muscle myogenesis contribute to the physiological function of muscles. Certain non-coding RNAs, including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are involved in the regulation of muscle development, and the aberrant expressions of lncRNAs and circRNAs are associated with muscular diseases. In this review, we summarize the recent advances concerning the roles of lncRNAs and circRNAs in regulating the developmental aspects of myogenesis. These findings have remarkably broadened our understanding of the gene regulation mechanisms governing muscle proliferation and differentiation, which makes it more feasible to design novel preventive, diagnostic and therapeutic strategies for muscle disorders.

Keywords: circRNAs; development; differentiation; lncRNAs; proliferation; skeletal muscle.

PubMed Disclaimer

References

REFERENCES

    1. Janssen I, Heymsfield SB, Wang Z, Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol. 2000;89(1):81-88.
    1. Silva WJ, Graça FA, Cruz A, et al. miR-29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy-related genes. Acta Physiol. 2019;226(4):e13278. https://doi.org/10.1111/apha.13278
    1. Appell HJ. Skeletal muscle atrophy during immobilization. Int J Sports Med. 1986;07(01):1-5.
    1. Zubrzycka-Gaarn EE, Bulman DE, Karpati G, et al. The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle. Nature. 1988;333(6172):466-469.
    1. Nicks DK, Beneke WM, Key RM, Timson BF. Muscle fibre size and number following immobilisation atrophy. J Anat. 1989;163:1-5.

Publication types

MeSH terms

LinkOut - more resources