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Comment
. 2019 Aug 1;176(8):668-669.
doi: 10.1176/appi.ajp.2019.19040374r.

Measurement Error Cannot Account for Failed Replications of Historic Candidate Gene-by-Environment Hypotheses: Response to Vrshek-Schallhorn et al

Richard Border  1 , Emma C Johnson  1 , Luke M Evans  1 , Matthew C Keller  1
Affiliations
Comment

Measurement Error Cannot Account for Failed Replications of Historic Candidate Gene-by-Environment Hypotheses: Response to Vrshek-Schallhorn et al

Richard Border et al. Am J Psychiatry. .
No abstract available

Keywords: Biological Markers; Genetics; Stress.

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References

    1. Border R, Johnson EC, Evans LM, et al.: No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples. Am J Psychiatry 2019; 176:376–387 - PMC - PubMed
    1. Culverhouse RC, Saccone NL, Horton AC, et al.: Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol Psychiatry 2018; 23:133–142 - PMC - PubMed
    1. Peterson RE, Cai N, Dahl AW, et al.: Molecular genetic analysis subdivided by adversity exposure suggests etiologic heterogeneity in major depression. Am J Psychiatry 2018; 175:545–554 - PMC - PubMed
    1. CONVERGE consortium: Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature 2015; 523:588–591 - PMC - PubMed
    1. Wray NR, Ripke S, Mattheisen M, et al.: Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 2018; 50:668–681 - PMC - PubMed

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