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Review
. 2019 Jun 26;11(6):159-170.
doi: 10.4330/wjc.v11.i6.159.

Broken heart: A matter of the endoplasmic reticulum stress bad management?

Souad Belmadani  1 , Khalid Matrougui  2
Affiliations
Review

Broken heart: A matter of the endoplasmic reticulum stress bad management?

Souad Belmadani et al. World J Cardiol. .

Abstract

Cardiovascular diseases are the number one cause of morbidity and mortality in the United States and worldwide. The induction of the endoplasmic reticulum (ER) stress, a result of a disruption in the ER homeostasis, was found to be highly associated with cardiovascular diseases such as hypertension, diabetes, ischemic heart diseases and heart failure. This review will discuss the latest literature on the different aspects of the involvement of the ER stress in cardiovascular complications and the potential of targeting the ER stress pathways as a new therapeutic approach for cardiovascular complications.

Keywords: Apoptosis; Autophagy; Endoplasmic reticulum stress; Heart complications; Inflammation.

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Conflict of interest statement

Conflict-of-interest statement: None

Figures

Figure 1
Figure 1
Schema recapitulating the involvement of the endoplasmic reticulum stress in heart diseases. ER: Endoplasmic reticulum.
See this image and copyright information in PMC

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