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Review
. 2019 Jul 25:9:36.
doi: 10.1186/s13601-019-0277-4. eCollection 2019.

Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm

Polliana Mihaela Leru  1   2
Affiliations
Review

Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm

Polliana Mihaela Leru. Clin Transl Allergy. .

Abstract

Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades, with consistent progress made regarding understanding of molecular mechanisms, refining of diagnostic criteria, classification and evaluation of therapeutic options. There are still many gaps and difficulties in evaluating eosinophilic syndromes and diseases in medical practice. The disease prognosis depends mainly on the cause and mechanism of eosinophilia, on severity of organ dysfunction and on accurate diagnosis and response to treatment. Besides primary hypereosinophilic syndromes and secondary (reactive) eosinophilias, many associated or idiopathic forms have been described, making this topic a complex and difficult medical entity. An important aim of the experts in the field is to agree upon a more clear and practically useful classification, a better characterization of various phenotypes and endotypes of eosinophilic diseases and to identify novel biomarkers and more effective therapies. The aim of this paper is to review recent data from the literature regarding definition, classification and diagnosis criteria of eosinophilic diseases and to propose a revised and updated diagnostic algorithm useful in clinical practice.

Keywords: Diagnostic criteria; Eosinophilic disorders; Hypereosinophilia; Hypereosinophilic syndrome; Practical diagnostic algorithm.

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Conflict of interest statement

Competing interestsThe author declares no conflict of interest in relation with this manuscript.

Figures

Fig. 1
Fig. 1
A proposed diagnostic algorithm of Hypereosinophilia and Eosinophilic diseases
See this image and copyright information in PMC

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